Get started
Keyword

BRD4

Description: A bromodomain-containing protein that binds acetylated chromatin and regulates gene transcription, studied in cancer biology and other biomedical research.
OpenAlex ID: keywords/brd4
Selective inhibition of BET bromodomains
2010 · Panagis Filippakopoulos, Jun Qi, et al. · Nature · 4,207
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
2013 · Jakob Lovén, Heather A. Hoke, et al. · Cell · 2,954
PDF
Coactivator condensation at super-enhancers links phase separation and gene control
2018 · Benjamin R. Sabari, Alessandra Dall’Agnese, et al. · Science · 2,587
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
2011 · Johannes Zuber, Junwei Shi, et al. · Nature · 1,861
Phthalimide conjugation as a strategy for in vivo target protein degradation
2015 · Georg E. Winter, Dennis L. Buckley, et al. · Science · 1,724
Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
2012 · Panagis Filippakopoulos, Sarah Picaud, et al. · Cell · 1,697
PDF
Suppression of inflammation by a synthetic histone mimic
2010 · Edwige Nicodeme, Kate L. Jeffrey, et al. · Nature · 1,547
Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
2018 · Won-Ki Cho, Jan-Hendrik Spille, et al. · Science · 1,402
Functions of N6-methyladenosine and its role in cancer
2019 · Liuer He, Huiyu Li, et al. · Molecular Cancer · 1,401
PDF
The Bromodomain Protein Brd4 Is a Positive Regulatory Component of P-TEFb and Stimulates RNA Polymerase II-Dependent Transcription
2005 · Moon Kyoo Jang, Kazuki Mochizuki, et al. · Molecular Cell · 1,294
PDF
Structural basis of PROTAC cooperative recognition for selective protein degradation
2017 · Morgan S Gadd, Andrea Testa, et al. · Nature Chemical Biology · 1,191
PDF
Recruitment of P-TEFb for Stimulation of Transcriptional Elongation by the Bromodomain Protein Brd4
2005 · Zhiyuan Yang, Jasper H.N. Yik, et al. · Molecular Cell · 1,138
PDF
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4
2015 · Jing Lu, Yimin Qian, et al. · Chemistry & Biology · 1,115
PDF
The dTAG system for immediate and target-specific protein degradation
2018 · Behnam Nabet, Justin M. Roberts, et al. · Nature Chemical Biology · 1,111
Organization of Chromatin by Intrinsic and Regulated Phase Separation
2019 · Bryan A. Gibson, Lynda K. Doolittle, et al. · Cell · 1,075
PDF
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
2015 · Michael Zengerle, Kwok-Ho Chan, et al. · ACS Chemical Biology · 1,031
PDF
Imaging dynamic and selective low-complexity domain interactions that control gene transcription
2018 · Shasha Chong, Claire Dugast-Darzacq, et al. · Science · 966
Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
2014 · Irfan A. Asangani, Vijaya L. Dommeti, et al. · Nature · 927
The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition
2014 · Junwei Shi, Christopher R. Vakoc · Molecular Cell · 878
PDF
mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis
2018 · Junho Choe, Shuibin Lin, et al. · Nature · 746
Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma
2013 · Bjoern Chapuy, Michael R. McKeown, et al. · Cancer Cell · 734
PDF
BRD4 and Cancer: going beyond transcriptional regulation
2018 · Benedetta Donati, Eugenia Lorenzini, et al. · Molecular Cancer · 711
PDF
The Double Bromodomain-containing Chromatin Adaptor Brd4 and Transcriptional Regulation
2007 · Shwu-Yuan Wu, Cheng-Ming Chiang · Journal of Biological Chemistry · 679
PDF
The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis
2003 · Anup Dey, Farideh Chitsaz, et al. · Proceedings of the National Academy of Sciences · 669
Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation
2009 · Diana C. Hargreaves, Tiffany Horng, et al. · Cell · 646
PDF
Works count: 6,087
Citation count: 156,000
Year
Topic
Type