Get started
Keyword

C75

Description: C75 is a synthetic small-molecule inhibitor of fatty acid synthase studied in metabolism, appetite regulation, and cancer research.
OpenAlex ID: keywords/c75
Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors
2000 · Thomas M. Loftus, Donna E. Jaworsky, et al. · Science · 1,004
Synthesis and antitumor activity of an inhibitor of fatty acid synthase
2000 · Francis P. Kuhajda, Ellen S. Pizer, et al. · Proceedings of the National Academy of Sciences · 567
Fatty Acid Synthase As a Potential Therapeutic Target in Cancer
2010 · Richard Flavin, Stephane Peluso, et al. · Future Oncology · 545
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.
2000 · E S Pizer, J Thupari, et al. · PubMed · 366
Pharmacological Inhibition of AMP-activated Protein Kinase Provides Neuroprotection in Stroke
2005 · Louise D. McCullough, Zhiyuan Zeng, et al. · Journal of Biological Chemistry · 333
Inhibition of fatty acid synthase (FAS) suppresses HER2/neu ( erb B-2) oncogene overexpression in cancer cells
2004 · Javier A. Menendez, Luciano Vellon, et al. · Proceedings of the National Academy of Sciences · 327
C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase
2004 · Eun-Kyoung Kim, Ian Miller, et al. · Journal of Biological Chemistry · 303
Hypothalamic malonyl-CoA as a mediator of feeding behavior
2003 · Zhiyuan Hu, Seung Hun Cha, et al. · Proceedings of the National Academy of Sciences · 272
C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity
2002 · Jagan N. Thupari, Leslie E. Landree, et al. · Proceedings of the National Academy of Sciences · 262
Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines.
1998 · E S Pizer, F J Chrest, et al. · PubMed · 250
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
2015 · Jong-Seok Moon, Seonmin Lee, et al. · Journal of Clinical Investigation · 238
PDF
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.
2003 · Weibo Zhou, P Jeanette Simpson, et al. · PubMed · 216
Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production
2008 · Wei Yang, Brian L. Hood, et al. · Hepatology · 207
PDF
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
2005 · Hui Qin Wang, Deborah A Altomare, et al. · Oncogene · 198
Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation
2019 · Young-Chan Kim, Sang Eun Lee, et al. · Nature Chemical Biology · 190
Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides
2001 · Teruhiko Shimokawa, Monica V. Kumar, et al. · Proceedings of the National Academy of Sciences · 186
Green Tea Epigallocatechin Gallate: A Natural Inhibitor of Fatty-Acid Synthase
2001 · Xuan Wang, Weixi Tian · Biochemical and Biophysical Research Communications · 183
West Nile Virus Replication Requires Fatty Acid Synthesis but Is Independent on Phosphatidylinositol-4-Phosphate Lipids
2011 · Miguel A. Martín-Acebes, Ana-Belén Blázquez, et al. · PLoS ONE · 172
PDF
Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice
2004 · Patricia M Alli, Michael L Pinn, et al. · Oncogene · 167
Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.
2001 · J N Li, M Gorospe, et al. · PubMed · 166
Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma
2012 · Aadra P. Bhatt, Sarah R. Jacobs, et al. · Proceedings of the National Academy of Sciences · 163
PDF
1-11C-Acetate as a PET Radiopharmaceutical for Imaging Fatty Acid Synthase Expression in Prostate Cancer
2008 · Amy L. Vāvere, Steven J. Kridel, et al. · Journal of Nuclear Medicine · 154
PDF
Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice
2002 · Monica V. Kumar, Teruhiko Shimokawa, et al. · Proceedings of the National Academy of Sciences · 151
Fatty acid oxidation and meiotic resumption in mouse oocytes
2009 · Stephen M. Downs, Jessica L. Mosey, et al. · Molecular Reproduction and Development · 147
Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells
2010 · Quanri Jin, Linda X Yuan, et al. · Breast Cancer Research · 145
PDF
Works count: 345
Citation count: 13,970
Year
Topic
Type