Keyword

Cas9

Description: A CRISPR-associated microbial protein that uses guide RNA to recognize and cut targeted DNA sequences in genome editing and immunity.

Primary topic: CRISPR and Genetic Engineering (78%)

Wikidata ID: wiki/Q16965677

OpenAlex ID: keywords/cas9

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

2013 · Lei S. Qi, Matthew H. Larson, et al. · Cell · 5,005

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Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

2012 · Giedrius Gasiunas, Rodolphe Barrangou, et al. · Proceedings of the National Academy of Sciences · 2,767

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Rationally engineered Cas9 nucleases with improved specificity

2015 · Ian M. Slaymaker, Linyi Gao, et al. · Science · 2,415

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

2014 · Sangsu Bae, Jeongbin Park, et al. · Bioinformatics · 2,336

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RNA-programmed genome editing in human cells

2013 · Martin Jinek, Alexandra East, et al. · eLife · 2,098

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DNA interrogation by the CRISPR RNA-guided endonuclease Cas9

2014 · Samuel H. Sternberg, Sy Redding, et al. · Nature · 1,760

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Highly efficient Cas9-mediated transcriptional programming

2015 · Alejandro Chavez, Jonathan Scheiman, et al. · Nature Methods · 1,619

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Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

2018 · Johnny H. Hu, Shannon M. Miller, et al. · Nature · 1,551

Macromolecular Crowding: Biochemical, Biophysical, and Physiological Consequences

1993 · S B Zimmerman, A P Minton · Annual Review of Biophysics and Biomolecular Structure · 1,510

The next generation of CRISPR–Cas technologies and applications

2019 · Adrian Pickar-Oliver, Charles A. Gersbach · Nature Reviews Molecular Cell Biology · 1,458

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

2014 · Carolin Anders, Ole Niewoehner, et al. · Nature · 1,298

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

2015 · Sergey Shmakov, Omar O. Abudayyeh, et al. · Molecular Cell · 1,235

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Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

2014 · Martin Jinek, Fuguo Jiang, et al. · Science · 1,229

DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins

2015 · Je Wook Woo, Jungeun Kim, et al. · Nature Biotechnology · 1,216

CRISPR interference (CRISPRi) for sequence-specific control of gene expression

2013 · Matthew H Larson, Luke A Gilbert, et al. · Nature Protocols · 1,214

A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action

2006 · Kira S Makarova, Nick V Grishin, et al. · Biology Direct · 1,197

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CRISPR/Cas9 in Genome Editing and Beyond

2016 · Haifeng Wang, Marie La Russa, et al. · Annual Review of Biochemistry · 1,158

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The Control of Protein Stability and Association by Weak Interactions with Water: How Do Solvents Affect These Processes?

1993 · S N Timasheff · Annual Review of Biophysics and Biomolecular Structure · 1,108

Diversity and evolution of class 2 CRISPR–Cas systems

2017 · Sergey Shmakov, Aaron Smargon, et al. · Nature Reviews Microbiology · 1,066

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

2014 · Xuebing Wu, David A Scott, et al. · Nature Biotechnology · 944

Targeted mutagenesis in rice using CRISPR-Cas system

2013 · Jin Miao, Dongshu Guo, et al. · Cell Research · 917

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The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli

2011 · Rimantas Sapranauskas, Giedrius Gasiunas, et al. · Nucleic Acids Research · 835

CRISPR-P: A Web Tool for Synthetic Single-Guide RNA Design of CRISPR-System in Plants

2014 · Yang Lei, Li Lu, et al. · Molecular Plant · 806

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Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems

2016 · Prarthana Mohanraju, Kira S. Makarova, et al. · Science · 673

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

2014 · Richard L Frock, Jiazhi Hu, et al. · Nature Biotechnology · 672

Works count: 2,364

Citation count: 97,510