Keyword

CCN5

Description: A secreted signaling protein in the CCN family that influences cell growth and movement, including in vascular and other tissues.

Primary topic: Connective Tissue Growth Factor Research (52%)

OpenAlex ID: keywords/ccn5

The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis

2010 · Pyoung Oh Yoon, Min-Ah Lee, et al. · Journal of Molecular and Cellular Cardiology · 143

CCN Proteins - A New Family of Cell Growth and Differentiation Regulators

2005 · Perbal, Bernard V., Takigawa, Masaharu · IMPERIAL COLLEGE PRESS eBooks · 134

Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis

2016 · Dongtak Jeong, Min-Ah Lee, et al. · Journal of the American College of Cardiology · 126

Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)

2015 · JUN LI, LIN YE, et al. · International Journal of Molecular Medicine · 119

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CCN5, a Novel Transcriptional Repressor of the Transforming Growth Factor β Signaling Pathway

2011 · Michèle Sabbah, Céline Prunier, et al. · Molecular and Cellular Biology · 89

The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis.

2010 · Guo-Wei Zuo, Christopher D Kohls, et al. · PubMed · 87

Differential roles of CCN family proteins during osteoblast differentiation: Involvement of Smad and MAPK signaling pathways

2011 · Harumi Kawaki, Satoshi Kubota, et al. · Bone · 84

CCN5 Is a Growth Arrest-Specific Gene That Regulates Smooth Muscle Cell Proliferation and Motility

2003 · Andrew C. Lake, Ann Bialik, et al. · American Journal Of Pathology · 75

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Cysteine-rich 61-Connective Tissue Growth Factor-nephroblastoma-overexpressed 5 (CCN5)/Wnt-1-induced Signaling Protein-2 (WISP-2) Regulates MicroRNA-10b via Hypoxia-inducible Factor-1α-TWIST Signaling Networks in Human Breast Cancer Cells

2011 · Inamul Haque, Snigdha Banerjee, et al. · Journal of Biological Chemistry · 73

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The CCN family acting throughout the body: recent research developments

2013 · Satoshi Kubota, Masaharu Takigawa · BioMolecular Concepts · 69

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Targeting WNT1-inducible signaling pathway protein 2 alters human breast cancer cell susceptibility to specific lysis through regulation of KLF-4 and miR-7 expression

2014 · I Akalay, T Z Tan, et al. · Oncogene · 65

CCN5: biology and pathophysiology

2010 · Joshua W. Russo, John J. Castellot · Journal of Cell Communication and Signaling · 62

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2011 · Audrey Guillon-Munos, Katerina Oikonomopoulou, et al. · Journal of Biological Chemistry · 61

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Leptin-induced ER-α-positive breast cancer cell viability and migration is mediated by suppressing CCN5-signaling via activating JAK/AKT/STAT-pathway

2018 · Inamul Haque, Arnab Ghosh, et al. · BMC Cancer · 55

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Targeting CCN Proteins in Rheumatoid Arthritis and Osteoarthritis

2021 · Iona J. MacDonald, Chien-Chung Huang, et al. · International Journal of Molecular Sciences · 49

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Spatial-temporal modulation of CCN proteins during wound healing in human skin in vivo

2011 · Laure Rittié, Bernard Perbal, et al. · Journal of Cell Communication and Signaling · 47

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The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells

2004 · H. R. Mason · Molecular Human Reproduction · 47

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CCN5 modulates the antiproliferative effect of heparin and regulates cell motility in vascular smooth muscle cells

2003 · Andrew C Lake, John J Castellot · Cell Communication and Signaling · 47

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Proteins on the catwalk: modelling the structural domains of the CCN family of proteins

2009 · Kenneth P. Holbourn, Bernard Perbal, et al. · Journal of Cell Communication and Signaling · 45

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Loss of WISP2/CCN5 in Estrogen-Dependent MCF7 Human Breast Cancer Cells Promotes a Stem-Like Cell Phenotype

2014 · Nathalie Ferrand, Anne Gnanapragasam, et al. · PLoS ONE · 44

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CCN5 overexpression inhibits profibrotic phenotypes via the PI3K/Akt signaling pathway in lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis and in an in vivo model of lung fibrosis

2013 · LIN ZHANG, YINGNA LI, et al. · International Journal of Molecular Medicine · 42

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Alternative splicing of CCN mRNAs …. it has been upon us

2009 · Bernard Perbal · Journal of Cell Communication and Signaling · 40

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Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2)

2016 · Georgina S. Butler, Andrea R. Connor, et al. · Matrix Biology · 37

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CCN 2 and CCN 5 exerts opposing effect on fibroblast proliferation and transdifferentiation induced by TGF ‐β

2015 · Honghai Xu, Peng Li, et al. · Clinical and Experimental Pharmacology and Physiology · 35

Expression profles of human CCN genes in patients with osteoarthritis or rheumatoid arthritis

2015 · Masatoshi Komatsu, Yukio Nakamura, et al. · Journal of Orthopaedic Science · 35

Works count: 169

Citation count: 2,494