Keyword

CD19

Description: CD19 is a cell-surface protein expressed by B lymphocytes that helps regulate their activation, development, and signaling in immunology research.

Primary topic: CAR-T cell therapy research (36%)

Wikidata ID: wiki/Q798033

OpenAlex ID: keywords/cd19

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

2014 · Shannon L. Maude, Noelle Frey, et al. · New England Journal of Medicine · 5,405

PDF

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

2018 · Stephen J. Schuster, Michael R. Bishop, et al. · New England Journal of Medicine · 4,091

PDF

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

2011 · David L. Porter, Bruce L. Levine, et al. · New England Journal of Medicine · 3,561

PDF

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

2013 · Stephan A. Grupp, Michael Kalos, et al. · New England Journal of Medicine · 3,504

PDF

Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study

2020 · Jeremy S Abramson, M Lia Palomba, et al. · The Lancet · 2,417

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

2011 · Michael Kalos, Bruce L. Levine, et al. · Science Translational Medicine · 2,388

Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia

2017 · Hagop Kantarjian, Anthony Stein, et al. · New England Journal of Medicine · 2,145

PDF

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

2017 · Stephen J. Schuster, Jakub Svoboda, et al. · New England Journal of Medicine · 1,861

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

2017 · Justin Eyquem, Jorge Mansilla-Soto, et al. · Nature · 1,828

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

2015 · Adrienne H Long, Waleed M Haso, et al. · Nature Medicine · 1,807

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

2015 · David L. Porter, Wei-Ting Hwang, et al. · Science Translational Medicine · 1,725

The Basic Principles of Chimeric Antigen Receptor Design

2013 · Michel Sadelain, Renier Brentjens, et al. · Cancer Discovery · 1,537

Update on the Autoimmune Pathology of Multiple Sclerosis: B-Cells as Disease-Drivers and Therapeutic Targets

2015 · H.-Christian von Büdingen, Arumugam Palanichamy, et al. · European Neurology · 1,463

Long-term outcomes following CAR T cell therapy: what we know so far

2023 · Kathryn M. Cappell, James N. Kochenderfer · Nature Reviews Clinical Oncology · 1,389

PDF

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

2017 · Terry J Fry, Nirali N Shah, et al. · Nature Medicine · 1,338

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

2010 · James N. Kochenderfer, Wyndham H. Wilson, et al. · Blood · 1,335

Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study

2014 · Max S Topp, Nicola Gökbuget, et al. · The Lancet Oncology · 1,268

CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

2018 · Theodoros Giavridis, Sjoukje J. C. van der Stegen, et al. · Nature Medicine · 1,267

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

2015 · Elena Sotillo, David M. Barrett, et al. · Cancer Discovery · 1,255

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

2008 · Koichi Yanaba, Jean-David Bouaziz, et al. · Immunity · 1,238

PDF

Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy

2021 · Emma C. Morris, Sattva S. Neelapu, et al. · Nature reviews. Immunology · 1,107

PDF

CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

2011 · Barbara Savoldo, Carlos Almeida Ramos, et al. · Journal of Clinical Investigation · 1,021

Stepwise Reprogramming of B Cells into Macrophages

2004 · Huafeng Xie, Min Ye, et al. · Cell · 949

PDF

Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia

2018 · Bianca D. Santomasso, Jae H. Park, et al. · Cancer Discovery · 938

Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

2022 · J. Joseph Melenhorst, Gregory M. Chen, et al. · Nature · 924

Works count: 10,720

Citation count: 268,800