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Keyword

CD39

Description: A cell-surface enzyme encoded by ENTPD1 that hydrolyzes extracellular nucleotides and influences immune regulation and signaling.
Wikidata ID: wiki/Q17859534
OpenAlex ID: keywords/cd39
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
2007 · Silvia Deaglio, Karen M. Dwyer, et al. · The Journal of Experimental Medicine · 2,473
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Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
2009 · Michael R. Elliott, Faraaz B. Chekeni, et al. · Nature · 1,653
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
2018 · Yannick Simoni, Etienne Becht, et al. · Nature · 1,365
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression
2007 · Giovanna Borsellino, Markus Kleinewietfeld, et al. · Blood · 1,287
CD39 and CD73 in immunity and inflammation
2013 · Luca Antonioli, Pál Pacher, et al. · Trends in Molecular Medicine · 1,264
Negative feedback control of neuronal activity by microglia
2020 · Ana Badimon, Hayley J. Strasburger, et al. · Nature · 974
Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
2018 · Thomas Duhen, Rebekka Duhen, et al. · Nature Communications · 937
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The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance
2006 · Simon C. Robson, Jean Sévigny, et al. · Purinergic Signalling · 932
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The ectonucleotidases CD 39 and CD 73: Novel checkpoint inhibitor targets
2017 · Bertrand Allard, Maria Serena Longhi, et al. · Immunological Reviews · 923
Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor
2017 · Tomasz Maj, Wei Wang, et al. · Nature Immunology · 733
Molecular Approach to Adenosine Receptors: Receptor-Mediated Mechanisms of Tissue Protection
2001 · J Linden · The Annual Review of Pharmacology and Toxicology · 685
Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
2002 · Kristin Synnestvedt, Glenn T. Furuta, et al. · Journal of Clinical Investigation · 679
Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
2002 · Kristin Synnestvedt, Glenn T. Furuta, et al. · Journal of Clinical Investigation · 659
Identification and Characterization of CD39/Vascular ATP Diphosphohydrolase
1996 · Elzbieta Kaczmarek, Katarzyna Koziak, et al. · Journal of Biological Chemistry · 583
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Extracellular adenosine triphosphate and adenosine in cancer
2010 · J Stagg, M J Smyth · Oncogene · 571
Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
1999 · Keiichi Enjyoji, Jean Sévigny, et al. · Nature Medicine · 565
Extracellular purines, purinergic receptors and tumor growth
2016 · F Di Virgilio, E Adinolfi · Oncogene · 561
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Targeting adenosine for cancer immunotherapy
2018 · Robert D. Leone, Leisha A. Emens · Journal for ImmunoTherapy of Cancer · 545
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Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production
2011 · Aled Clayton, Saly Al-Taei, et al. · The Journal of Immunology · 541
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Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39
2019 · Maisa C. Takenaka, Galina Gabriely, et al. · Nature Neuroscience · 516
Coordinated Adenine Nucleotide Phosphohydrolysis and Nucleoside Signaling in Posthypoxic Endothelium
2003 · Holger K. Eltzschig, Juan C. Ibla, et al. · The Journal of Experimental Medicine · 499
Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells
2010 · Roopali Gandhi, Deepak Kumar, et al. · Nature Immunology · 476
CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis
2009 · Jean M Fletcher, Roisin Lonergan, et al. · The Journal of Immunology · 476
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Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α
2015 · Ivan D Mascanfroni, Maisa C Takenaka, et al. · Nature Medicine · 440
Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies
2019 · Ivan Perrot, Henri-Alexandre Michaud, et al. · Cell Reports · 424
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Works count: 3,997
Citation count: 101,300
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