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Keyword

CDK2

Description: A human gene encoding cyclin-dependent kinase 2, a cell-cycle regulatory protein studied in cancer biology and drug development.
Wikidata ID: wiki/Q14911732
OpenAlex ID: keywords/cdk2
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
1993 · J Wade Harper · Cell · 5,652
The history and future of targeting cyclin-dependent kinases in cancer therapy
2015 · Uzma Asghar, Agnieszka K. Witkiewicz, et al. · Nature Reviews Drug Discovery · 1,747
Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2
2016 · William W. Du, Weining Yang, et al. · Nucleic Acids Research · 1,696
Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors
1996 · Keiko Nakayama, Keiko Nakayama, et al. · Cell · 1,547
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Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
1993 · J Gyuris · Cell · 1,522
Inhibition of Histone Deacetylase Activity by Butyrate
2003 · James R. Davie · Journal of Nutrition · 1,507
Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis
2010 · Jesper V. Olsen, Michiel Vermeulen, et al. · Science Signaling · 1,480
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
1994 · Vjekoslav Dulić, William K. Kaufmann, et al. · Cell · 1,466
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
1995 · Philip D. Jeffrey, Alicia A. Russo, et al. · Nature · 1,436
Cyclin A is required at two points in the human cell cycle.
1992 · M. Pagano, R. Pepperkok, et al. · The EMBO Journal · 1,403
Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5
1997 · Laurent Meijer, Annie Borgne, et al. · European Journal of Biochemistry · 1,347
Mammalian cyclin-dependent kinases
2005 · Marcos Malumbres, Mariano Barbacid · Trends in Biochemical Sciences · 1,295
The Pezcoller lecture: cancer cell cycles revisited.
2000 · C J Sherr · PubMed · 1,196
Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control
1993 · Sander van den Heuvel, Ed Harlow · Science · 1,092
Living with or without cyclins and cyclin-dependent kinases
2004 · Charles J. Sherr, James M. Roberts · Genes & Development · 1,089
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The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
2001 · Jacob Falck, Niels Mailand, et al. · Nature · 1,084
Cdk Phosphorylation Triggers Sequential Intramolecular Interactions that Progressively Block Rb Functions as Cells Move through G1
1999 · J.William Harbour, Robin X Luo, et al. · Cell · 1,055
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Recycling the Cell Cycle
2004 · Andrew W Murray · Cell · 1,053
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Formation and Activation of a Cyclin E-cdk2 Complex During the G 1 Phase of the Human Cell Cycle
1992 · Andrew Koff, Antonio Giordano, et al. · Science · 1,043
Inhibition of cyclin-dependent kinases by p21.
1995 · J W Harper, S J Elledge, et al. · Molecular Biology of the Cell · 1,023
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
1992 · Yue Xiong, Hui Zhang, et al. · Cell · 1,019
Myostatin, a Negative Regulator of Muscle Growth, Functions by Inhibiting Myoblast Proliferation
2000 · Mark Thomas, Brett Langley, et al. · Journal of Biological Chemistry · 1,014
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
1993 · Mark E. Ewen, Hayla K. Sluss, et al. · Cell · 1,010
Crystal structure of cyclin-dependent kinase 2
1993 · Hendrik L. De Bondt, Jody Rosenblatt, et al. · Nature · 976
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.
1995 · I Reynisdóttir, K Polyak, et al. · Genes & Development · 962
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Works count: 10,760
Citation count: 370,100
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