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Keyword

celastrol

Description: Celastrol is a naturally occurring bioactive chemical compound studied for its pharmacological effects in cancer, inflammatory diseases, and other biomedical contexts.
Wikidata ID: wiki/Q5057534
OpenAlex ID: keywords/celastrol
Treatment of Obesity with Celastrol
2015 · Junli Liu, Jaemin Lee, et al. · Cell · 724
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Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials
2007 · Timothy W. Corson, Craig M. Crews · Cell · 654
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Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
2006 · Haley Hieronymus, Justin Lamb, et al. · Cancer Cell · 625
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Celastrol, a Triterpene Extracted from the Chinese “Thunder of God Vine,” Is a Potent Proteasome Inhibitor and Suppresses Human Prostate Cancer Growth in Nude Mice
2006 · Huanjie Yang, Di Chen, et al. · Cancer Research · 587
Broad targeting of angiogenesis for cancer prevention and therapy
2015 · Zongwei Wang, Charlotta Dabrosin, et al. · Seminars in Cancer Biology · 466
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Celastrols as Inducers of the Heat Shock Response and Cytoprotection
2004 · Sandy D. Westerheide, Joshua D. Bosman, et al. · Journal of Biological Chemistry · 427
Triterpenoids as new promising anticancer drugs
2009 · Alessia Petronelli, Gaetano Pannitteri, et al. · Anti-Cancer Drugs · 381
Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1
2021 · Piao Luo, Dandan Liu, et al. · Acta Pharmaceutica Sinica B · 380
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Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease
2001 · Anthony C. Allison, Ramon Cacabelos, et al. · Progress in Neuro-Psychopharmacology and Biological Psychiatry · 374
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells
2008 · Tao Zhang, Adel Hamza, et al. · Molecular Cancer Therapeutics · 363
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Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer
2010 · Radhamani Kannaiyan, Muthu K. Shanmugam, et al. · Cancer Letters · 346
Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis
2015 · Xinran Ma, Lingyan Xu, et al. · Cell Metabolism · 337
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Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB–regulated gene products and TAK1-mediated NF-κB activation
2006 · Gautam Sethi, Kwang Seok Ahn, et al. · Blood · 337
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Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy
2016 · Prasad R. Dandawate, Dharmalingam Subramaniam, et al. · Seminars in Cancer Biology · 327
A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F
2018 · Shao-Ru Chen, Yan Dai, et al. · Frontiers in Pharmacology · 326
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Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy
2017 · Mengjie Hu, Qiang Luo, et al. · Molecular Cell · 319
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Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer
2010 · Vivek R. Yadav, Sahdeo Prasad, et al. · Toxins · 318
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Targeting apoptosis pathways in cancer by Chinese medicine
2010 · Min Li-Weber · Cancer Letters · 318
Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid
2006 · Jeong-Hyung Lee, Jeong-Hyung Lee, et al. · Biochemical Pharmacology · 308
Celastrol: Molecular targets of Thunder God Vine
2010 · Antero Salminen, Marko Lehtonen, et al. · Biochemical and Biophysical Research Communications · 293
Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells
2020 · Xi Chen, Ying Zhao, et al. · Theranostics · 292
TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers
2012 · C Freudlsperger, Y Bian, et al. · Oncogene · 290
Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study
2015 · H-Y Li, J Zhang, et al. · Cell Death and Disease · 284
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Exosomal formulation enhances therapeutic response of celastrol against lung cancer
2016 · Farrukh Aqil, Hina Kausar, et al. · Experimental and Molecular Pathology · 269
Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis
2021 · Caifeng Deng, Quan Zhang, et al. · Nature Communications · 252
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Works count: 2,531
Citation count: 61,180
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