Keyword

cGAS

Description: A cytosolic DNA-sensing enzyme that produces cyclic GMP-AMP and activates innate immune signaling through the STING pathway.

Primary topic: interferon and immune responses (51%)

Wikidata ID: wiki/Q18049130

OpenAlex ID: keywords/cgas

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

2012 · Lijun Sun, Jiaxi Wu, et al. · Science · 4,943

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

2016 · Qi Chen, Lijun Sun, et al. · Nature Immunology · 2,305

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

2014 · Liufu Deng, Hua Liang, et al. · Immunity · 2,168

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Molecular mechanisms and cellular functions of cGAS–STING signalling

2020 · Karl-Peter Hopfner, Veit Hornung · Nature Reviews Molecular Cell Biology · 2,023

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

2015 · Siqi Liu, Xin Cai, et al. · Science · 1,918

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

2014 · Seng-Ryong Woo, Mercedes B. Fuertes, et al. · Immunity · 1,900

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cGAS surveillance of micronuclei links genome instability to innate immunity

2017 · Karen J. Mackenzie, Paula Carroll, et al. · Nature · 1,735

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

2013 · Andrea Ablasser, Marion Goldeck, et al. · Nature · 1,675

Mitotic progression following DNA damage enables pattern recognition within micronuclei

2017 · Shane M. Harding, Joseph L. Benci, et al. · Nature · 1,497

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Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

2022 · Shugang Qin, Wen Xiao, et al. · Signal Transduction and Targeted Therapy · 1,476

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DNA sensing by the cGAS–STING pathway in health and disease

2019 · Mona Motwani, Scott Pesiridis, et al. · Nature Reviews Genetics · 1,463

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

2018 · Tuo Li, Zhijian J. Chen · The Journal of Experimental Medicine · 1,284

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

2019 · Xiang Gui, Hui Yang, et al. · Nature · 1,260

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

2017 · Selene Glück, Baptiste Guey, et al. · Nature Cell Biology · 1,188

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

2013 · Pu Gao, Manuel Ascano, et al. · Cell · 1,090

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Structural basis of STING binding with and phosphorylation by TBK1

2019 · Conggang Zhang, Guijun Shang, et al. · Nature · 1,076

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

2018 · Mingjian Du, Zhijian J. Chen · Science · 1,076

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

2013 · Xu Zhang, Heping Shi, et al. · Molecular Cell · 1,073

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cGAS in action: Expanding roles in immunity and inflammation

2019 · Andrea Ablasser, Zhijian J. Chen · Science · 1,071

cGAS is essential for cellular senescence

2017 · Hui Yang, Hanze Wang, et al. · Proceedings of the National Academy of Sciences · 1,005

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Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

2013 · Daxing Gao, Jiaxi Wu, et al. · Science · 994

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

2014 · Xin Cai, Yu-Hsin Chiu, et al. · Molecular Cell · 989

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Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

2014 · Michael J. White, Kate McArthur, et al. · Cell · 975

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Significance of Respiratory Symptoms and the Diagnosis of Chronic Bronchitis in a Working Population

1959 · C. M. Fletcher, P. C. Elmes, et al. · BMJ · 971

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Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer

2019 · Triparna Sen, B. Leticia Rodriguez, et al. · Cancer Discovery · 895

Works count: 3,073

Citation count: 124,600