Keyword

CHEK2

Description: CHEK2 is a human gene encoding a checkpoint kinase involved in DNA damage responses and associated with inherited cancer susceptibility.

Primary topic: BRCA gene mutations in cancer (60%)

Wikidata ID: wiki/Q14912280

OpenAlex ID: keywords/chek2

Integrated Genomic Characterization of Papillary Thyroid Carcinoma

2014 · Nishant Agrawal, Rehan Akbani, et al. · Cell · 3,067

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DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

2015 · Joaquin Mateo, Suzanne Carreira, et al. · New England Journal of Medicine · 2,184

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Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

2016 · Colin C. Pritchard, Joaquin Mateo, et al. · New England Journal of Medicine · 1,680

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Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations

2002 · Hanne Meijers-Heijboer, Ans van den Ouweland, et al. · Nature Genetics · 1,106

Whole-genome landscape of pancreatic neuroendocrine tumours

2017 · Australian Pancreatic Cancer Genome Initiative, Aldo Scarpa, et al. · Nature · 1,001

Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing

2011 · Tom Walsh, Silvia Casadei, et al. · Proceedings of the National Academy of Sciences · 933

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Cancer therapy shapes the fitness landscape of clonal hematopoiesis

2020 · Kelly L. Bolton, Ryan N. Ptashkin, et al. · Nature Genetics · 749

BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors

2019 · Andrew Lee, Nasim Mavaddat, et al. · Genetics in Medicine · 723

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Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer

2016 · Rachel Pearlman, Wendy L. Frankel, et al. · JAMA Oncology · 708

Spectrum of Mutations in BRCA1, BRCA2, CHEK2, and TP53 in Families at High Risk of Breast Cancer

2006 · Tom Walsh, Silvia Casadei, et al. · JAMA · 666

Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer

2017 · Fergus J. Couch, Hermela Shimelis, et al. · JAMA Oncology · 613

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Breast and Ovarian Cancer

2003 · Richard Wooster, Barbara L. Weber · New England Journal of Medicine · 606

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Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer

2016 · Nadine Tung, Nancy U. Lin, et al. · Journal of Clinical Oncology · 556

CHEK2 Is a Multiorgan Cancer Susceptibility Gene

2004 · C. Cybulski, B. Górski, et al. · The American Journal of Human Genetics · 551

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A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

2017 · Paz Polak, Jaegil Kim, et al. · Nature Genetics · 529

Genetics of breast cancer: a topic in evolution

2015 · S. Shiovitz, L.A. Korde · Annals of Oncology · 527

Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer

2017 · Matthew B. Yurgelun, Matthew H. Kulke, et al. · Journal of Clinical Oncology · 524

TBCRC 048: Phase II Study of Olaparib for Metastatic Breast Cancer and Mutations in Homologous Recombination-Related Genes

2020 · Nadine M. Tung, Mark E. Robson, et al. · Journal of Clinical Oncology · 508

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Ten Genes for Inherited Breast Cancer

2007 · Tom Walsh, Mary-Claire King · Cancer Cell · 477

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CHEK2*1100delC and Susceptibility to Breast Cancer: A Collaborative Analysis Involving 10,860 Breast Cancer Cases and 9,065 Controls from 10 Studies

2004 · * · The American Journal of Human Genetics · 471

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Prevalence of Homologous Recombination–Related Gene Mutations Across Multiple Cancer Types

2018 · Arielle L. Heeke, Michael J. Pishvaian, et al. · JCO Precision Oncology · 470

A CHEK2 Genetic Variant Contributing to a Substantial Fraction of Familial Breast Cancer

2002 · Pia Vahteristo, Jirina Bartkova, et al. · The American Journal of Human Genetics · 467

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Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

2014 · Yufei Wang, James D McKay, et al. · Nature Genetics · 454

Frequency of mutations in individuals with breast cancer referred for BRCA 1 and BRCA 2 testing using next‐generation sequencing with a 25‐gene panel

2014 · Nadine Tung, Chiara Battelli, et al. · Cancer · 430

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A study of over 35,000 women with breast cancer tested with a 25‐gene panel of hereditary cancer genes

2017 · Saundra S. Buys, John F. Sandbach, et al. · Cancer · 399

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Works count: 3,186

Citation count: 62,730