Keyword

chimeric toxin

Description: An engineered toxin combining a toxin component with a targeting molecule to deliver toxic activity selectively, especially in cancer therapy.

Primary topic: Toxin Mechanisms and Immunotoxins (60%)

OpenAlex ID: keywords/chimeric-toxin

Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein

1987 · D.P. Williams, K. Parker, et al. · Protein Engineering Design and Selection · 236

Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma.

2000 · R W Rand, R J Kreitman, et al. · PubMed · 222

Human glioma cells overexpress receptors for interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and pseudomonas exotoxin.

1995 · W Debinski, N I Obiri, et al. · PubMed · 216

Ribosomally encoded antibacterial proteins and peptides fromPseudomonas

2014 · Maarten G.K. Ghequire, René De Mot · FEMS Microbiology Reviews · 214

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Ganglioside Structure Dictates Signal Transduction by Cholera Toxin and Association with Caveolae-like Membrane Domains in Polarized Epithelia

1998 · Anne A. Wolf, Michael G. Jobling, et al. · The Journal of Cell Biology · 213

Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL.

1991 · S. Seetharam, V.K. Chaudhary, et al. · Journal of Biological Chemistry · 212

A Novel Chimeric Protein Composed of Interleukin 13 and Pseudomonas Exotoxin Is Highly Cytotoxic to Human Carcinoma Cells Expressing Receptors for Interleukin 13 and Interleukin 4

1995 · Waldemar Debinski, Nicholas I. Obiri, et al. · Journal of Biological Chemistry · 208

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Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin.

1987 · V K Chaudhary, D J FitzGerald, et al. · Proceedings of the National Academy of Sciences · 181

Ribosome-Inactivating Proteins: From Plant Defense to Tumor Attack

2010 · Maddalena de Virgilio, Alessio Lombardi, et al. · Toxins · 157

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Targeted Toxin Therapy for the Treatment of Cancer

1989 · D. FitzGerald, I. Pastan · JNCI Journal of the National Cancer Institute · 156

Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells.

1990 · C B Siegall, G Schwab, et al. · PubMed · 152

In vitro and in vivo studies of a VEGF 121 /rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors

2002 · Liesbeth M. Veenendaal, Hangqing Jin, et al. · Proceedings of the National Academy of Sciences · 142

Genetic construction, expression, and melanoma-selective cytotoxicity of a diphtheria toxin-related alpha-melanocyte-stimulating hormone fusion protein.

1986 · J R Murphy, W Bishai, et al. · Proceedings of the National Academy of Sciences · 133

A 12-Amino-Acid Segment, Present in Type s2 but Not Type s1 Helicobacter pylori VacA Proteins, Abolishes Cytotoxin Activity and Alters Membrane Channel Formation

2001 · Mark S. McClain, Ping Cao, et al. · Journal of Bacteriology · 127

Pseudomonas exotoxin: chimeric toxins

1989 · I Pastan, D FitzGerald · Journal of Biological Chemistry · 125

Chimeric toxins

1981 · Shur Olsnes, Alexander Pihl · Pharmacology & Therapeutics · 123

Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin A (PE38QQR)

1996 · RK Puri, P Leland, et al. · Blood · 115

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Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma.

1996 · R K Puri, D S Hoon, et al. · PubMed · 110

Vascular endothelial growth factor chimeric toxin is highly active against endothelial cells.

1999 · N Arora, R Masood, et al. · PubMed · 106

Molecular Basis of the High Insecticidal Potency of Scorpion α-Toxins

2004 · Izhar Karbat, Felix Frolow, et al. · Journal of Biological Chemistry · 103

Structural determinants for membrane insertion, pore formation and translocation ofClostridium difficiletoxin B

2011 · Selda Genisyuerek, Panagiotis Papatheodorou, et al. · Molecular Microbiology · 102

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A chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly.

1993 · P. Aullo, M. Giry, et al. · The EMBO Journal · 95

Functional domains of Bacillus thuringiensis insecticidal crystal proteins. Refinement of Heliothis virescens and Trichoplusia ni specificity domains on CryIA(c).

1991 · A.Z. Ge, D. Rivers, et al. · Journal of Biological Chemistry · 95

Scorpion Toxins Specific for Potassium (K+) Channels: A Historical Overview of Peptide Bioengineering

2012 · Zachary L. Bergeron, Jon-Paul Bingham · Toxins · 91

Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells

2005 · Riccardo Vago, Catherine J. Marsden, et al. · FEBS Journal · 91

Works count: 360

Citation count: 9,160