Keyword

CHOP

Description: CHOP is a stress-responsive transcription factor involved in endoplasmic reticulum stress and apoptosis, studied in cellular and disease biology.

Primary topic: Endoplasmic Reticulum Stress and Disease (36%)

OpenAlex ID: keywords/chop

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 · Heather P Harding, Isabel Novoa, et al. · Molecular Cell · 3,278

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Roles of CHOP/GADD153 in endoplasmic reticulum stress

2003 · S Oyadomari, M Mori · Cell Death and Differentiation · 2,832

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 · H. Zinszner, M. Kuroda, et al. · Genes & Development · 2,016

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

2004 · Stefan J. Marciniak, Chi Y. Yun, et al. · Genes & Development · 2,003

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Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

2001 · Karen D. McCullough, Jennifer L. Martindale, et al. · Molecular and Cellular Biology · 1,892

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

2013 · Jaeseok Han, Sung Hoon Back, et al. · Nature Cell Biology · 1,686

ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

2007 · Hamsa Puthalakath, Lorraine A. O'Reilly, et al. · Cell · 1,426

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Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

2001 · Isabel Novoa, Huiqing Zeng, et al. · The Journal of Cell Biology · 1,387

IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response

2007 · Jonathan H. Lin, Han Li, et al. · Science · 1,371

Coping with stress: eIF2 kinases and translational control

2006 · R.C. Wek, H.-Y. Jiang, et al. · Biochemical Society Transactions · 1,289

Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation

2007 · Naomi Hosogai, Atsunori Fukuhara, et al. · Diabetes · 1,256

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Endoplasmic reticulum stress in liver disease

2010 · Harmeet Malhi, Randal J. Kaufman · Journal of Hepatology · 1,177

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

2013 · Wafa B’chir, Anne-Catherine Maurin, et al. · Nucleic Acids Research · 1,155

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The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection

2019 · Hai Hu, Mingxing Tian, et al. · Frontiers in Immunology · 1,136

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Cell death induced by endoplasmic reticulum stress

2015 · Raffaella Iurlaro, Cristina Muñoz‐Pinedo · FEBS Journal · 1,065

A mitochondrial specific stress response in mammalian cells

2002 · Quan Zhao, Jianghui Wang, et al. · The EMBO Journal · 1,026

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TRB3, a novel ER stress‐inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death

2005 · Nobumichi Ohoka, Satoshi Yoshii, et al. · The EMBO Journal · 1,016

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ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to the cis -Acting Element Responsible for the Mammalian Unfolded Protein Response

2000 · Hiderou Yoshida, Tetsuya Okada, et al. · Molecular and Cellular Biology · 934

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

1993 · Anne Crozat, Pierre Åman, et al. · Nature · 896

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

2003 · Bo Feng, Pin Mei Yao, et al. · Nature Cell Biology · 886

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 · XiaoZhong Wang, David Ron · Science · 883

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

2012 · T Verfaillie, N Rubio, et al. · Cell Death and Differentiation · 852

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CHOP Is Involved in Endoplasmic Reticulum Stress-induced Apoptosis by Enhancing DR5 Expression in Human Carcinoma Cells

2004 · Hirohito Yamaguchi, Hong-Gang Wang · Journal of Biological Chemistry · 832

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

2007 · D. R. Laybutt, A. M. Preston, et al. · Diabetologia · 829

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The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

2009 · Kasper M.A. Rouschop, Twan van den Beucken, et al. · Journal of Clinical Investigation · 826

Works count: 9,734

Citation count: 275,800