Keyword

combinatorial chemistry

Description: A chemical synthesis approach that produces and screens many related compounds to identify useful molecules, including potential drug candidates.

Primary topic: Chemical Synthesis and Analysis (38%)

Wikidata ID: wiki/Q899212

OpenAlex ID: keywords/combinatorial-chemistry

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

2020 · David J. Newman, Gordon M. Cragg · Journal of Natural Products · 7,025

Comprehensive organic synthesis

2014 · Paul Knochel, Gary A. Molander · Elsevier eBooks · 6,221

Natural Products as Sources of New Drugs over the Last 25 Years

2007 · David J. Newman, Gordon M. Cragg · Journal of Natural Products · 5,516

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

2012 · David J. Newman, Gordon M. Cragg · Journal of Natural Products · 4,674

The growing impact of click chemistry on drug discovery

2003 · Hartmuth C Kolb, K.Barry Sharpless · Drug Discovery Today · 3,149

Natural Products as Sources of New Drugs over the Period 1981−2002

2003 · David J. Newman, Gordon M. Cragg, et al. · Journal of Natural Products · 3,082

Natural products: A continuing source of novel drug leads

2013 · Gordon M. Cragg, David J. Newman · Biochimica et Biophysica Acta (BBA) - General Subjects · 2,907

Organic Azides: An Exploding Diversity of a Unique Class of Compounds

2005 · Stefan Bräse, Carmen Gil, et al. · Angewandte Chemie International Edition · 2,233

ADMET in silico modelling: towards prediction paradise?

2003 · Han van de Waterbeemd, Eric Gifford · Nature Reviews Drug Discovery · 1,863

Natural products in drug discovery

2008 · Alan L. Harvey · Drug Discovery Today · 1,840

Handbook of Metathesis

2003 · Wiley eBooks · 1,671

A Planning Strategy for Diversity‐Oriented Synthesis

2003 · Martin D. Burke, Stuart L. Schreiber · Angewandte Chemie International Edition · 1,496

Synthesis and Applications of Small Molecule Libraries

1996 · Lorin A. Thompson, Jonathan A. Ellman · Chemical Reviews · 1,453

Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity

2011 · Eelco Ruijter, Rachel Scheffelaar, et al. · Angewandte Chemie International Edition · 1,330

Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions

1994 · Eric M. Gordon, Ronald W. Barrett, et al. · Journal of Medicinal Chemistry · 1,142

Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries

1994 · Mark A. Gallop, Ronald W. Barrett, et al. · Journal of Medicinal Chemistry · 1,135

Diffusion NMR Spectroscopy in Supramolecular and Combinatorial Chemistry: An Old Parameter—New Insights

2004 · Yoram Cohen, Liat Avram, et al. · Angewandte Chemie International Edition · 1,123

Multiple-Component Condensation Strategies for Combinatorial Library Synthesis

1996 · Robert W. Armstrong, Andrew P. Combs, et al. · Accounts of Chemical Research · 1,111

Recent Advances in the Biginelli Dihydropyrimidine Synthesis. New Tricks from an Old Dog

2000 · C. Oliver Kappe · Accounts of Chemical Research · 1,104

A decade of fragment-based drug design: strategic advances and lessons learned

2007 · Philip J. Hajduk, Jonathan Greer · Nature Reviews Drug Discovery · 1,065

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

2001 · William R. Oliver, Jennifer L. Shenk, et al. · Proceedings of the National Academy of Sciences · 1,046

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“Multi-component Reactions : Emerging Chemistry in Drug Discovery” ‘From Xylocain to Crixivan’

2003 · Christopher Hulme, Vijay Gore · Current Medicinal Chemistry · 1,035

Click chemistry reactions in medicinal chemistry: Applications of the 1,3‐dipolar cycloaddition between azides and alkynes

2007 · Gian Cesare Tron, Tracey Pirali, et al. · Medicinal Research Reviews · 996

Virtual screening—an overview

1998 · W.Patrick Walters, Matthew T Stahl, et al. · Drug Discovery Today · 994

Recent Developments in the Isonitrile‐Based Multicomponent Synthesis of Heterocycles

2003 · Jieping Zhu · European Journal of Organic Chemistry · 956

Works count: 6,541

Citation count: 189,700