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Keyword

complex diseases

Description: Diseases arising from interactions among multiple genetic, environmental, and lifestyle factors rather than a single cause.
Wikidata ID: wiki/Q3281220
OpenAlex ID: keywords/complex-diseases
UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
2015 · Cathie Sudlow, John Gallacher, et al. · PLoS Medicine · 12,650
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Finding the missing heritability of complex diseases
2009 · Teri A. Manolio, Francis S. Collins, et al. · Nature · 8,317
The Future of Genetic Studies of Complex Human Diseases
1996 · Neil Risch, Kathleen Merikangas · Science · 5,348
Network medicine: a network-based approach to human disease
2010 · Albert-László Barabási, Natali Gulbahce, et al. · Nature Reviews Genetics · 5,010
Genomic Control for Association Studies
1999 · B. Devlin, Kathryn Roeder · Biometrics · 3,157
Parametric and nonparametric linkage analysis: a unified multipoint approach.
1996 · L Kruglyak, M J Daly, et al. · PubMed · 2,883
Drug Discovery: A Historical Perspective
2000 · Jürgen Drews · Science · 2,766
Meta-analysis in clinical trials revisited
2015 · Rebecca DerSimonian, Nan Laird · Contemporary Clinical Trials · 2,662
Partitioning heritability by functional annotation using genome-wide association summary statistics
2015 · Hilary K Finucane, Brendan Bulik-Sullivan, et al. · Nature Genetics · 2,589
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Human non-synonymous SNPs: server and survey
2002 · V. Ramensky · Nucleic Acids Research · 2,280
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Biological robustness
2004 · Hiroaki Kitano, Fumitoshi Matsuno · Nature Reviews Genetics · 2,262
SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci
2005 · Yong Yong SHI, Lin HE · Cell Research · 2,224
The microbiome and innate immunity
2016 · Christoph A. Thaiss, Niv Zmora, et al. · Nature · 2,010
Tutorial: a guide to performing polygenic risk score analyses
2020 · Shing Wan Choi, Timothy Shin-Heng Mak, et al. · Nature Protocols · 1,947
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Polygenic prediction via Bayesian regression and continuous shrinkage priors
2019 · Tian Ge, Chia-Yen Chen, et al. · Nature Communications · 1,904
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Alzheimer Mechanisms and Therapeutic Strategies
2012 · Yadong Huang, Lennart Mucke · Cell · 1,756
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A genomic mutational constraint map using variation in 76,156 human genomes
2023 · Siwei Chen, Laurent C. Francioli, et al. · Nature · 1,699
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Missing heritability and strategies for finding the underlying causes of complex disease
2010 · Evan E. Eichler, Jonathan Flint, et al. · Nature Reviews Genetics · 1,688
Genotype imputation for genome-wide association studies
2010 · Jonathan Marchini, Bryan Howie · Nature Reviews Genetics · 1,630
Genomewide Association Studies and Assessment of the Risk of Disease
2010 · Teri A. Manolio · New England Journal of Medicine · 1,512
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An atlas of genetic influences on human blood metabolites
2014 · So-Youn Shin, Eric B Fauman, et al. · Nature Genetics · 1,510
Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease
2003 · David Botstein, Neil Risch · Nature Genetics · 1,505
The distribution of fitness effects of new mutations
2007 · Adam Eyre-Walker, Peter D. Keightley · Nature Reviews Genetics · 1,479
Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix
2005 · J Li, L Ji · Heredity · 1,449
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Association study designs for complex diseases
2001 · Lon R. Cardon, John I. Bell · Nature Reviews Genetics · 1,396
Works count: 9,887
Citation count: 316,900
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