Keyword

complex I

Description: A mitochondrial enzyme complex that transfers electrons from NADH to ubiquinone and couples this reaction to proton pumping in cellular respiration.

Primary topic: Mitochondrial Function and Pathology (42%)

OpenAlex ID: keywords/complex-i

How mitochondria produce reactive oxygen species

2008 · Michael P. Murphy · Biochemical Journal · 8,188

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A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

2008 · David J. Pagliarini, Sarah E. Calvo, et al. · Cell · 1,995

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Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

1988 · I. J. Holt, A. E. Harding, et al. · Nature · 1,846

P LANT M ITOCHONDRIA AND O XIDATIVE S TRESS : Electron Transport, NADPH Turnover, and Metabolism of Reactive Oxygen Species

2001 · Ian M Møller · Annual Review of Plant Physiology and Plant Molecular Biology · 1,665

Production of Reactive Oxygen Species by Mitochondria

2003 · Qun Chen, Edwin J. Vazquez, et al. · Journal of Biological Chemistry · 1,616

Topology of Superoxide Production from Different Sites in the Mitochondrial Electron Transport Chain

2002 · Julie St-Pierre, Julie A. Buckingham, et al. · Journal of Biological Chemistry · 1,544

Mitochondrial electron transport chain, ROS generation and uncoupling (Review)

2019 · Ru‑Zhou Zhao, Shuai Jiang, et al. · International Journal of Molecular Medicine · 1,398

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Supercomplexes in the respiratory chains of yeast and mammalian mitochondria

2000 · Hermann Schägger, Kathy Pfeiffer · The EMBO Journal · 1,355

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

2008 · Bong-Hyun Ahn, Hyun-Seok Kim, et al. · Proceedings of the National Academy of Sciences · 1,292

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Generation of reactive oxygen species by the mitochondrial electron transport chain

2002 · Yuanbin Liu, Gary Fiskum, et al. · Journal of Neurochemistry · 1,261

Classification and phylogeny of hydrogenases

2001 · Paulette M. Vignais, Bernard Billoud, et al. · FEMS Microbiology Reviews · 1,189

Abnormalities of the electron transport chain in idiopathic parkinson's disease

1989 · William Davis Parker, Sally J. Boyson, et al. · Annals of Neurology · 1,063

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

2016 · Martin D. Brand · Free Radical Biology and Medicine · 1,059

Complex III Releases Superoxide to Both Sides of the Inner Mitochondrial Membrane

2004 · Florian L. Muller, Yuhong Liu, et al. · Journal of Biological Chemistry · 1,033

Function of Mitochondrial Stat3 in Cellular Respiration

2009 · Joanna Wegrzyn, Ramesh Potla, et al. · Science · 1,013

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High-Resolution Respirometry: OXPHOS Protocols for Human Cells and Permeabilized Fibers from Small Biopsies of Human Muscle

2011 · Dominik Pesta, Erich Gnaiger · Methods in molecular biology · 1,003

Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice

2004 · James J. Palacino, Dijana Sagi, et al. · Journal of Biological Chemistry · 995

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 · K Schulze-Osthoff, A.C. Bakker, et al. · Journal of Biological Chemistry · 940

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

1997 · Susan E. Browne, Allen C. Bowling, et al. · Annals of Neurology · 883

Persistent inhibition of cell respiration by nitric oxide: Crucial role of S -nitrosylation of mitochondrial complex I and protective action of glutathione

1998 · Emilio Clementi, Guy Charles Brown, et al. · Proceedings of the National Academy of Sciences · 865

Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

1977 · Enrique Cadenas, Alberto Boveris, et al. · Archives of Biochemistry and Biophysics · 858

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

2013 · Esther Lapuente-Brun, Raquel Moreno-Loshuertos, et al. · Science · 829

Mitochondrial proton and electron leaks

2010 · Martin Jastroch, Ajit S. Divakaruni, et al. · Essays in Biochemistry · 828

Energy Converting NADH: Quinone Oxidoreductase (Complex I)

2006 · Ulrich Brandt · Annual Review of Biochemistry · 815

The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains

1992 · John E. Walker · Quarterly Reviews of Biophysics · 781

Works count: 5,833

Citation count: 261,900