Keyword

complex traits

Description: In genetics, complex traits are characteristics shaped by multiple genetic and environmental influences, often showing continuous variation rather than discrete categories.

Primary topic: Genetic Associations and Epidemiology (40%)

Wikidata ID: wiki/Q55608248

OpenAlex ID: keywords/complex-traits

The UK Biobank resource with deep phenotyping and genomic data

2018 · Clare Bycroft, Colin Freeman, et al. · Nature · 8,829

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Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

2018 · Marie Verbanck, Chia-Yen Chen, et al. · Nature Genetics · 8,568

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GCTA: A Tool for Genome-wide Complex Trait Analysis

2010 · Jian Yang, S. Hong Lee, et al. · The American Journal of Human Genetics · 8,236

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TASSEL: software for association mapping of complex traits in diverse samples

2007 · Peter J. Bradbury, Zhiwu Zhang, et al. · Bioinformatics · 7,775

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The GTEx Consortium atlas of genetic regulatory effects across human tissues

2020 · François Aguet, Shankara Anand, et al. · Science · 5,484

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Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 · Eric Lander, Leonid Kruglyak · Nature Genetics · 5,240

METAL: fast and efficient meta-analysis of genomewide association scans

2010 · Cristen J. Willer, Yun Li, et al. · Bioinformatics · 5,191

Common SNPs explain a large proportion of the heritability for human height

2010 · Jian Yang, Beben Benyamin, et al. · Nature Genetics · 4,426

An atlas of genetic correlations across human diseases and traits

2015 · Brendan Bulik-Sullivan, Hilary K Finucane, et al. · Nature Genetics · 4,245

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MAGMA: Generalized Gene-Set Analysis of GWAS Data

2015 · Christiaan A. de Leeuw, Joris M. Mooij, et al. · PLoS Computational Biology · 3,629

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Genetic Dissection of Complex Traits

1994 · Eric S. Lander, Nicholas J. Schork · Science · 3,421

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

2016 · Zhihong Zhu, Futao Zhang, et al. · Nature Genetics · 3,313

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

2008 · Mark I. McCarthy, Gonçalo R. Abecasis, et al. · Nature Reviews Genetics · 2,890

Genome-wide association studies for common diseases and complex traits

2005 · Joel N. Hirschhorn, Mark J. Daly · Nature Reviews Genetics · 2,864

An Expanded View of Complex Traits: From Polygenic to Omnigenic

2017 · Evan A. Boyle, Yang I. Li, et al. · Cell · 2,845

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Meta-analysis of the heritability of human traits based on fifty years of twin studies

2015 · Tinca J C Polderman, Beben Benyamin, et al. · Nature Genetics · 2,464

Integrative approaches for large-scale transcriptome-wide association studies

2016 · Alexander Gusev, Arthur Ko, et al. · Nature Genetics · 2,461

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Five Years of GWAS Discovery

2012 · Peter M. Visscher, Matthew A. Brown, et al. · The American Journal of Human Genetics · 2,425

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Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

2018 · Loic Yengo, Julia Sidorenko, et al. · Human Molecular Genetics · 2,371

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Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

2011 · Michael C. Wu, Seunggeun Lee, et al. · The American Journal of Human Genetics · 2,359

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Schizophrenia as a Complex Trait

2003 · Patrick F. Sullivan, Kenneth S. Kendler, et al. · Archives of General Psychiatry · 2,357

Allelic Variation of Human Serotonin Transporter Gene Expression

1996 · Armin Heils, Andreas Teufel, et al. · Journal of Neurochemistry · 2,221

Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits

2002 · S. Purcell, S. S. Cherny, et al. · Bioinformatics · 2,057

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Origins and functional impact of copy number variation in the human genome

2009 · Donald F. Conrad, Dalila Pinto, et al. · Nature · 1,971

A gene-based association method for mapping traits using reference transcriptome data

2015 · Eric R Gamazon, Heather E Wheeler, et al. · Nature Genetics · 1,832

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Works count: 7,200

Citation count: 383,300