Keyword

COX-2 expression

Description: The production of cyclooxygenase-2 RNA or protein in cells or tissues, measured in studies of inflammation and disease.

Primary topic: Inflammatory mediators and NSAID effects (39%)

OpenAlex ID: keywords/cox-2-expression

Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of COX-2

2007 · Andrew T. Chan, Shuji Ogino, et al. · New England Journal of Medicine · 781

PDF

Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

1997 · H Sheng, J Shao, et al. · Journal of Clinical Investigation · 713

PDF

Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer.

1999 · O N Tucker, A J Dannenberg, et al. · PubMed · 690

Differential effects of prostaglandin derived from ω-6 and ω-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion

2003 · Dilprit Bagga, Ling Wang, et al. · Proceedings of the National Academy of Sciences · 639

Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice

1997 · H Mizuno, C Sakamoto, et al. · Gastroenterology · 637

PDF

COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer

1998 · S. Buckman · Carcinogenesis · 590

Aspirin Use and Survival After Diagnosis of Colorectal Cancer

2009 · Andrew T. Chan · JAMA · 557

COX‐2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX‐2 inhibitor celecoxib

2001 · Sabine Grösch, Irmgard Tegeder, et al. · The FASEB Journal · 501

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis

1999 · Susan M. Fischer, Herng-Hsang Lo, et al. · Molecular Carcinogenesis · 408

Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells

2001 · Ajay Goel, C.Richard Boland, et al. · Cancer Letters · 381

Cyclooxygenase-2: Regulation and relevance in inflammation

1995 · Jane A. Mitchell, Simon Larkin, et al. · Biochemical Pharmacology · 371

Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression.

1997 · D J Elder, D E Halton, et al. · PubMed · 366

Expression of cyclooxygenase-2 in prostate carcinoma

2000 · Rikio Yoshimura, Hajime Sano, et al. · Cancer · 335

PDF

Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines.

2000 · T Hida, K Kozaki, et al. · PubMed · 320

The effect of extracts from ginger rhizome on inflammatory mediator production

2006 · R.C. Lantz, G.J. Chen, et al. · Phytomedicine · 306

Expression of cyclooxygenase 2 in human malignant melanoma.

2001 · C Denkert, M Köbel, et al. · PubMed · 287

Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder.

1999 · S I Mohammed, D W Knapp, et al. · PubMed · 285

Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues11Abbreviations: COX, cyclooxygenase; LOX, lipoxygenase; EGCG, (-)-epigallocatechin-3-gallate; EGC, (-)-epigallocatechin; ECG, (-)-epicatechin-3-gallate; EC, (-)-epicatechin; TF, theaflavin; TF3-G, theaflavin 3-gallate; TF3′-G, theaflavin 3′-gallate; TFdiG, theaflavin 3,3′-digallate; PGE2, prostaglandin E2; HETE, hydroxyeicosatetraenoic acid; HHT, 12-hydroxyheptadecatrienoic acid; and TBX, thromboxane.

2001 · Jungil Hong, Theresa J Smith, et al. · Biochemical Pharmacology · 262

The effect of turmeric extracts on inflammatory mediator production

2005 · R.C. Lantz, G.J. Chen, et al. · Phytomedicine · 254

Cyclooxygenase-2 Expression in The Barrettʼs Metaplasia–Dysplasia–Adenocarcinoma Sequence

2001 · Clive D Morris, Gordon R Armstrong, et al. · The American Journal of Gastroenterology · 251

Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in the human prostate

2000 · Alexander Kirschenbaum, Adam P Klausner, et al. · Urology · 234

Pathogenesis of NSAID-induced gastric damage: Importance of cyclooxygenase inhibition and gastric hypermotility

2012 · Koji Takeuchi · World Journal of Gastroenterology · 227

PDF

Up-regulation of cyclooxygenase-2 in squamous carcinogenesis of the esophagus.

2000 · A Shamma, H Yamamoto, et al. · PubMed · 206

Celecoxib exhibits the greatest potency amongst cyclooxygenase (COX) inhibitors for growth inhibition of COX-2-negative hematopoietic and epithelial cell lines.

2002 · Chris Waskewich, Rosalyn D Blumenthal, et al. · PubMed · 203

Inhibition of cancer cell proliferation and suppression of TNF-induced activation of NFkappaB by edible berry juice.

2007 · Dominique Boivin, Mélanie Blanchette, et al. · PubMed · 192

Works count: 2,916

Citation count: 37,690