Keyword

CRISPR interference

Description: CRISPR interference is a genetic perturbation method that uses nuclease-inactive CRISPR proteins to repress targeted gene expression.

Primary topic: CRISPR and Genetic Engineering (41%)

Wikidata ID: wiki/Q28208918

OpenAlex ID: keywords/crispr-interference

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

2013 · Lei S. Qi, Matthew H. Larson, et al. · Cell · 5,003

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CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

2013 · Luke A. Gilbert, Matthew H. Larson, et al. · Cell · 3,690

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Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

2014 · Luke A. Gilbert, Max A. Horlbeck, et al. · Cell · 2,724

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CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

2008 · Luciano A. Marraffini, Erik J. Sontheimer · Science · 1,741

Genetic compensation induced by deleterious mutations but not gene knockdowns

2015 · Andrea Rossi, Zacharias Kontarakis, et al. · Nature · 1,249

CRISPR interference (CRISPRi) for sequence-specific control of gene expression

2013 · Matthew H Larson, Luke A Gilbert, et al. · Nature Protocols · 1,214

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

2016 · Britt Adamson, Thomas M. Norman, et al. · Cell · 1,210

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Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

2018 · Kendall R. Sanson, Ruth E. Hanna, et al. · Nature Communications · 1,036

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CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

2010 · Luciano A. Marraffini, Erik J. Sontheimer · Nature Reviews Genetics · 1,009

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

2016 · Max A Horlbeck, Luke A Gilbert, et al. · eLife · 890

Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation

2015 · Antonia A. Dominguez, Wendell A. Lim, et al. · Nature Reviews Molecular Cell Biology · 830

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells

2016 · S. John Liu, Max A. Horlbeck, et al. · Science · 747

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Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence

2011 · Ekaterina Semenova, Matthijs M. Jore, et al. · Proceedings of the National Academy of Sciences · 744

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

2022 · Joseph M. Replogle, Reuben A. Saunders, et al. · Cell · 718

A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria

2016 · Jason M. Peters, Alexandre Colavin, et al. · Cell · 714

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Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems

2016 · Prarthana Mohanraju, Kira S. Makarova, et al. · Science · 673

Systematic mapping of functional enhancer–promoter connections with CRISPR interference

2016 · Charles P. Fulco, Mathias Munschauer, et al. · Science · 640

Self versus non-self discrimination during CRISPR RNA-directed immunity

2010 · Luciano A. Marraffini, Erik J. Sontheimer · Nature · 637

CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

2019 · Ruilin Tian, Mariam A. Gachechiladze, et al. · Neuron · 538

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Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

2017 · Jeremy M. Rock, Forrest F. Hopkins, et al. · Nature Microbiology · 537

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

2016 · Mohammad A. Mandegar, Nathaniel Huebsch, et al. · Cell stem cell · 524

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Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing

2020 · Joseph M. Replogle, Thomas M. Norman, et al. · Nature Biotechnology · 464

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Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element

2018 · Seung Woo Cho, Jin Xu, et al. · Cell · 458

CRISPR-Cas9 Based Engineering of Actinomycetal Genomes

2015 · Yaojun Tong, Pep Charusanti, et al. · ACS Synthetic Biology · 434

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes

2016 · Bastiaan Evers, Katarzyna Jastrzebski, et al. · Nature Biotechnology · 418

Works count: 2,600

Citation count: 71,150