Keyword

cryptolepine

Description: Cryptolepine is a plant-derived alkaloid studied for its biological activity, including effects on cellular signaling and cancer growth.

Primary topic: Synthesis and bioactivity of alkaloids (30%)

Wikidata ID: wiki/Q5190964

OpenAlex ID: keywords/cryptolepine

Antibacterial activity of alkaloids from Sida acuta

2005 · Damintoti Simplice Karou, Aly Savadogo, et al. · TSpace (University of Toronto) · 268

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In Vitro and in Vivo Antiplasmodial Activity of Cryptolepine and Related Alkaloids from Cryptolepis sanguinolenta

1997 · Kanyanga Cimanga, Tess De Bruyne, et al. · Journal of Natural Products · 255

The DNA Intercalating Alkaloid Cryptolepine Interferes with Topoisomerase II and Inhibits Primarily DNA Synthesis in B16 Melanoma Cells

1998 · K. Bonjean, M. C. De Pauw-Gillet, et al. · Biochemistry · 216

Synthesis and Evaluation of Cryptolepine Analogues for Their Potential as New Antimalarial Agents

2001 · Colin W. Wright, Jonathan Addae-Kyereme, et al. · Journal of Medicinal Chemistry · 193

Indoloquinolines as Scaffolds for Drug Discovery

2010 · J. Lavrado, R. Moreira, et al. · Current Medicinal Chemistry · 185

The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites

2001 · John N. Lisgarten, Miquel Coll, et al. · Nature Structural Biology · 184

Cytotoxicity and cell cycle effects of the plant alkaloids cryptolepine and neocryptolepine: relation to drug-induced apoptosis

2000 · Laurent Dassonneville, Amélie Lansiaux, et al. · European Journal of Pharmacology · 161

New Synthesis of Benzo-δ-carbolines, Cryptolepines, and Their Salts: In Vitro Cytotoxic, Antiplasmodial, and Antitrypanosomal Activities of δ-Carbolines, Benzo-δ-carbolines, and Cryptolepines

2001 · Erwan Arzel, Patrick Rocca, et al. · Journal of Medicinal Chemistry · 156

Synthesis, Cytotoxicity, and Antiplasmodial and Antitrypanosomal Activity of New Neocryptolepine Derivatives

2002 · Tim H. M. Jonckers, Sabine van Miert, et al. · Journal of Medicinal Chemistry · 154

Interactions of cryptolepine and neocryptolepine with unusual DNA structures

2003 · Lionel Guittat, Patrizia Alberti, et al. · Biochimie · 147

Ethnobotanical-Directed Discovery of the Antihyperglycemic Properties of Cryptolepine: Its Isolation from Cryptolepis sanguinolenta, Synthesis, and in Vitro and in Vivo Activities

1998 · Donald E. Bierer, Diana M. Fort, et al. · Journal of Medicinal Chemistry · 135

In VitroBiological Activities of Alkaloids fromCryptolepis sanguinolenta

1996 · Kanyanga Cimanga, Tess De Bruyne, et al. · Planta Medica · 126

Antiplasmodial Activity of Cryptolepis sanguinolenta Alkaloids from Leaves and Roots

2000 · Alexandra Paulo, Elsa T. Gomes, et al. · Planta Medica · 121

Studies on Cryptolepine

1981 · S. Bamgbose, B. Noamesi · Planta Medica · 116

In vitro and in vivo antimalarial activity of cryptolepine, a plant‐derived indoloquinoline

1995 · G. C. Kirby, A. Paine, et al. · Phytotherapy Research · 113

Isoneocryptolepine, a Synthetic Indoloquinoline Alkaloid, as an Antiplasmodial Lead Compound

2005 · Sabine Van Miert, Steven Hostyn, et al. · Journal of Natural Products · 112

Antimalarial Activity of Cryptolepine and Isocryptolepine, Alkaloids Isolated fromCryptolepis sanguinolenta

1996 · Phillippe Grellier, Lobo Ramiaramanana, et al. · Phytotherapy Research · 108

Positive and negative ion mode ESI-MS and MS/MS for studying drug–DNA complexes

2006 · Frédéric Rosu, Sophie Pirotte, et al. · International Journal of Mass Spectrometry · 106

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Antihyperglycemic Activities of Cryptolepine Analogues: An Ethnobotanical Lead Structure Isolated fromCryptolepis sanguinolenta

1998 · Donald E. Bierer, Larisa G. Dubenko, et al. · Journal of Medicinal Chemistry · 104

Stimulation of Topoisomerase II-Mediated DNA Cleavage by Three DNA-Intercalating Plant Alkaloids: Cryptolepine, Matadine, and Serpentine

1999 · Laurent Dassonneville, Karine Bonjean, et al. · Biochemistry · 103

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Constituents of West African Medicinal Plants XX: Quindoline from Cryptolepis sanguinolenta

1978 · Daniel Dwuma-Badu, John S.K. Ayim, et al. · Journal of Pharmaceutical Sciences · 102

Isolation, Biological Activities and Synthesis of Indoloquinoline Alkaloids: Cryptolepine, Isocryptolepine and Neocryptolepine

2011 · Prakash T. Parvatkar, Perunninakulath S. Parameswaran, et al. · Current Organic Chemistry · 99

Synthesis of Some Cryptolepine Analogues, Assessment of Their Antimalarial and Cytotoxic Activities, and Consideration of Their Antimalarial Mode of Action

2005 · Onyeka Onyeibor, Simon L. Croft, et al. · Journal of Medicinal Chemistry · 99

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Antimalarial Activity of Cryptolepine and Some Other Anhydronium Bases

1996 · C. W. Wright, J. D. Phillipson, et al. · Phytotherapy Research · 97

Plant Derived Antimalarial Agents: New Leads and Challenges

2005 · Colin W. Wright · Phytochemistry Reviews · 96

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Works count: 316

Citation count: 8,092