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Keyword

cyclopamine

Description: Cyclopamine is a naturally occurring steroidal alkaloid that inhibits Hedgehog signaling and is used in biomedical research on development and cancer.
Wikidata ID: wiki/Q3271319
OpenAlex ID: keywords/cyclopamine
Vertebrate Smoothened functions at the primary cilium
2005 · Kevin C. Corbit, Pia Aanstad, et al. · Nature · 1,480
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
2003 · Sarah P. Thayer, Marina Pasca di Magliano, et al. · Nature · 1,480
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
2002 · James K. Chen, Jussi Taipale, et al. · Genes & Development · 1,465
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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
2000 · Jussi Taipale, James K. Chen, et al. · Nature · 1,312
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
2003 · David M. Berman, Sunil S. Karhadkar, et al. · Nature · 1,251
HEDGEHOG-GLI1 Signaling Regulates Human Glioma Growth, Cancer Stem Cell Self-Renewal, and Tumorigenicity
2006 · Virginie Clement, Pilar Sanchez, et al. · Current Biology · 1,050
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Small molecule modulation of Smoothened activity
2002 · James K. Chen, Jussi Taipale, et al. · Proceedings of the National Academy of Sciences · 992
Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade
2002 · David M. Berman, Sunil S. Karhadkar, et al. · Science · 803
Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
2002 · Karen Lai, Brian K. Kaspar, et al. · Nature Neuroscience · 799
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
2007 · Matthias Lauth, Åsa Bergström, et al. · Proceedings of the National Academy of Sciences · 782
Blockade of Hedgehog Signaling Inhibits Pancreatic Cancer Invasion and Metastases: A New Paradigm for Combination Therapy in Solid Cancers
2007 · Georg Feldmann, Surajit Dhara, et al. · Cancer Research · 694
The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction
1998 · John P. Incardona, William Gaffield, et al. · Development · 656
The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance
2003 · Frédéric Charron, Elke Stein, et al. · Cell · 649
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Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma
2007 · Eli E. Bar, Aneeka Chaudhry, et al. · Stem Cells · 607
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Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography
2014 · Uwe Weierstall, Daniel James, et al. · Nature Communications · 584
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Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
2010 · James Kim, Jean Y. Tang, et al. · Cancer Cell · 527
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Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
2004 · Pilar Sanchez, Ana Maria Hernández, et al. · Proceedings of the National Academy of Sciences · 514
Essential Role forSonic hedgehogduring Hair Follicle Morphogenesis
1999 · Chin Chiang, Ryan Z. Swan, et al. · Developmental Biology · 497
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Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
2002 · Maria Frank-Kamenetsky, Xiaoyan M Zhang, et al. · Journal of Biology · 488
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The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
2001 · Nadia Dahmane, Pilar Sánchez, et al. · Development · 479
BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
2001 · Eleonora Minina, Hans Markus Wenzel, et al. · Development · 450
Hedgehog Signaling Pathway is a New Therapeutic Target for Patients with Breast Cancer
2004 · Makoto Kubo, Masafumi Nakamura, et al. · Cancer Research · 421
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Activation of the hedgehog pathway in advanced prostate cancer
2004 · Tao Sheng, Chengxin Li, et al. · Molecular Cancer · 378
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Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer
2009 · Maria–Theresa Mueller, Patrick C. Hermann, et al. · Gastroenterology · 348
Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon
2001 · Nicoletta Tekki-Kessaris, Rachel Woodruff, et al. · Development · 341
Works count: 1,997
Citation count: 74,190
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