Get started
Keyword

CYP2C19

Description: A human gene encoding a cytochrome P450 enzyme involved in metabolizing drugs and other compounds.
Wikidata ID: wiki/Q14916187
OpenAlex ID: keywords/cyp2c19
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
2013 · Ulrich M. Zanger, Matthias Schwab · Pharmacology & Therapeutics · 4,162
PDF
Cytochrome P-450 Polymorphisms and Response to Clopidogrel
2008 · Jessica L. Mega, Sandra L. Close, et al. · New England Journal of Medicine · 2,499
PDF
Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy
2009 · Alan R. Shuldiner · JAMA · 1,505
Standard- vs High-Dose Clopidogrel Based on Platelet Function Testing After Percutaneous Coronary Intervention
2011 · Matthew J. Price · JAMA · 1,308
Polymorphic Hydroxylation of Debrisoquine in Man
1977 · A Mahgoub, L.G Dring, et al. · The Lancet · 1,184
Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors
1997 · Slobodan Rendic, Frederick J. Di Carlo · Drug Metabolism Reviews · 1,172
Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
2007 · Magnus Ingelman-Sundberg, Sarah C. Sim, et al. · Pharmacology & Therapeutics · 1,166
Reduced-Function CYP2C19 Genotype and Risk of Adverse Clinical Outcomes Among Patients Treated With Clopidogrel Predominantly for PCI
2010 · Jessica L. Mega, Tabassome Simon, et al. · JAMA · 1,135
Cytochrome P450 Enzymes and Drug Metabolism in Humans
2021 · Mingzhe Zhao, Jingsong Ma, et al. · International Journal of Molecular Sciences · 1,057
PDF
Pharmacogenetics: From Bench to Byte— An Update of Guidelines
2011 · J J Swen, M Nijenhuis, et al. · Clinical Pharmacology & Therapeutics · 1,022
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors
2015 · JK Hicks, JR Bishop, et al. · Clinical Pharmacology & Therapeutics · 999
PDF
Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Clopidogrel Therapy: 2013 Update
2013 · S A Scott, K Sangkuhl, et al. · Clinical Pharmacology & Therapeutics · 964
PDF
The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.
1994 · S.M. de Morais, G.R. Wilkinson, et al. · Journal of Biological Chemistry · 957
Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism
2002 · Zeruesenay Desta, Xiaojiong Zhao, et al. · Clinical Pharmacokinetics · 942
Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
2006 · J.-S. Hulot · Blood · 932
PDF
The Human Intestinal Cytochrome P450 “pie”
2006 · Mary F. Paine, Heather L. Hart, et al. · Drug Metabolism and Disposition · 870
Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite
2009 · Miho Kazui, Yumi Nishiya, et al. · Drug Metabolism and Disposition · 836
Polymorphism of human cytochrome P450 enzymes and its clinical impact
2009 · Shu-Feng Zhou, Jun-Ping Liu, et al. · Drug Metabolism Reviews · 828
A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
2009 · D. N. Juurlink, T. Gomes, et al. · Canadian Medical Association Journal · 766
PDF
Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese.
1994 · S M De Morais, G R Wilkinson, et al. · Molecular Pharmacology · 752
Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel
2007 · J.T. BRANDT, S.L. CLOSE, et al. · Journal of Thrombosis and Haemostasis · 734
A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants
2006 · S SIM, C RISINGER, et al. · Clinical Pharmacology & Therapeutics · 733
Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response
2004 · J Kirchheiner, K Nickchen, et al. · Molecular Psychiatry · 726
Clinical assessment incorporating a personal genome
2010 · Euan A Ashley, Atul J Butte, et al. · The Lancet · 675
Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study
2002 · Jacques Fellay, Catia Marzolini, et al. · The Lancet · 658
Works count: 8,975
Citation count: 233,300
Year
Topic
Type