Keyword

CYP3A

Description: CYP3A is a family of cytochrome P450 enzymes involved in the metabolism of drugs and other compounds in animals.

Primary topic: Pharmacogenetics and Drug Metabolism (66%)

OpenAlex ID: keywords/cyp3a

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 · Steven A Kliewer, John T Moore, et al. · Cell · 1,539

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Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

2006 · Marcella Martignoni, Geny M M Groothuis, et al. · Expert Opinion on Drug Metabolism & Toxicology · 1,470

Vitamin D Receptor As an Intestinal Bile Acid Sensor

2002 · Makoto Makishima, Timothy T. Lu, et al. · Science · 1,173

Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism

2002 · Zeruesenay Desta, Xiaojiong Zhao, et al. · Clinical Pharmacokinetics · 942

The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism

2002 · Steven A. Kliewer, Bryan Goodwin, et al. · Endocrine Reviews · 921

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

1995 · Vincent J. Wacher, Chi‐Yuan Wu, et al. · Molecular Carcinogenesis · 857

Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

2000 · Linda B. Moore, Derek J. Parks, et al. · Journal of Biological Chemistry · 815

Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism

1997 · Mary F. Paine, Mehraneh Khalighi, et al. · Journal of Pharmacology and Experimental Therapeutics · 789

The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity

2001 · Ryan E. Watkins, G. Bruce Wisely, et al. · Science · 760

Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions

1997 · Richard J. Bertz, G. Richard Granneman · Clinical Pharmacokinetics · 755

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*

1996 · Kenneth E. Thummel, Diarmuid O'Shea, et al. · Clinical Pharmacology & Therapeutics · 617

Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis

1998 · Martin D. Weltman, Geoffrey C. Farrell, et al. · Hepatology · 614

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Cytochrome P450 3A

1999 · Saskia N. de Wildt, Gregory L. Kearns, et al. · Clinical Pharmacokinetics · 586

Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.

1993 · Z Abdel-Razzak, P Loyer, et al. · Molecular Pharmacology · 537

The Gut as a Barrier to Drug Absorption

2001 · Yuanchao Zhang, Leslie Z. Benet · Clinical Pharmacokinetics · 518

Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR

2000 · Wen Xie, Joyce L. Barwick, et al. · Genes & Development · 508

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How Important Are Gender Differences in Pharmacokinetics?

2002 · Bernd Meibohm, Ingrid Beierle, et al. · Clinical Pharmacokinetics · 454

Interrelationship Between Substrates and Inhibitors of Human CYP3A and P-Glycoprotein

1999 · Richard B. Kirn, Christoph Wandel, et al. · Pharmaceutical Research · 454

Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A Activity) during pregnancy

2005 · Timothy S. Tracy, Raman Venkataramanan, et al. · American Journal of Obstetrics and Gynecology · 448

Effect of age and gender on the activity of human hepatic CYP3A

1992 · Christine M. Hunt, William R. Westerkam, et al. · Biochemical Pharmacology · 426

Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes

2000 · Daniel S. Streetman, Joseph S. Bertino, et al. · Pharmacogenetics · 425

Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites

2006 · B LALOVIC, E KHARASCH, et al. · Clinical Pharmacology & Therapeutics · 419

Metabolism and Disposition of the Thienopyridine Antiplatelet Drugs Ticlopidine, Clopidogrel, and Prasugrel in Humans

2009 · Nagy A. Farid, Atsushi Kurihara, et al. · The Journal of Clinical Pharmacology · 398

The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms

2002 · D. Gail McCarver, Ronald N. Hines · Journal of Pharmacology and Experimental Therapeutics · 367

Cyclosporin Clinical Pharmacokinetics

1993 · Alfred Fahr · Clinical Pharmacokinetics · 356

Works count: 4,463

Citation count: 136,700