Keyword

daf-2

Description: A gene in the nematode Caenorhabditis elegans that encodes an insulin-like receptor and regulates development, metabolism, dauer formation, and lifespan.

Primary topic: Genetics, Aging, and Longevity in Model Organisms (70%)

OpenAlex ID: keywords/daf-2

A C. elegans mutant that lives twice as long as wild type

1993 · Cynthia Kenyon, Jean Chang, et al. · Nature · 3,385

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 · Koutarou D. Kimura, Heidi A. Tissenbaum, et al. · Science · 2,248

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

2002 · Martin Holzenberger, Joëlle Dupont, et al. · Nature · 2,109

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 · Scott Ogg, Suzanne Paradis, et al. · Nature · 1,933

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

2003 · Ao-Lin Hsu, Coleen T. Murphy, et al. · Science · 1,513

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 · Kui Lin, Jennie B. Dorman, et al. · Science · 1,496

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

2001 · Kui Lin, Honor Hsin, et al. · Nature Genetics · 1,040

Signals from the reproductive system regulate the lifespan of C. elegans

1999 · Honor Hsin, Cynthia Kenyon · Nature · 1,009

The genetics of caloric restriction in Caenorhabditis elegans

1998 · Bernard Lakowski, Siegfried Hekimi · Proceedings of the National Academy of Sciences · 962

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

2001 · Samuel T. Henderson, Thomas E. Johnson · Current Biology · 939

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Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

1995 · G J Lithgow, T M White, et al. · Proceedings of the National Academy of Sciences · 862

The daf‐2 gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression in Caenorhabditis elegans

1999 · Yoko Honda, Shuji Honda · The FASEB Journal · 730

Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans

1998 · David Gems, Amy J Sutton, et al. · Genetics · 717

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

2004 · Kailiang Jia, Di Chen, et al. · Development · 710

Mitochondrial Electron Transport Is a Key Determinant of Life Span in Caenorhabditis elegans

2001 · Jinliu Feng, Frédéric Bussière, et al. · Developmental Cell · 674

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Genes that regulate both development and longevity in Caenorhabditis elegans.

1995 · P L Larsen, P S Albert, et al. · Genetics · 584

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Widespread Proteome Remodeling and Aggregation in Aging C. elegans

2015 · Dirk M. Walther, Prasad Kasturi, et al. · Cell · 568

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Insulin/insulin-like growth factor signaling in C. elegans

2013 · Coleen T. Murphy · WormBook · 545

Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes

1996 · Bernard Lakowski, Siegfried Hekimi · Science · 542

Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans

2004 · Cheng Huang, Chengjie Xiong, et al. · Proceedings of the National Academy of Sciences · 530

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway

2001 · Raymond Y.N. Lee, Jürgen Hench, et al. · Current Biology · 504

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Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway

1999 · Jun Nakae, Byung-Chul Park, et al. · Journal of Biological Chemistry · 470

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Genetics and the Specificity of the Aging Process

2003 · Siegfried Hekimi, Leonard Guarente · Science · 434

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

2012 · Kim Zarse, Sebastian Schmeisser, et al. · Cell Metabolism · 430

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A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

1999 · S. Paradis, M. Ailion, et al. · Genes & Development · 428

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Works count: 816

Citation count: 49,410