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Keyword

dCas9

Description: A catalytically inactive form of the CRISPR-associated Cas9 protein used to target DNA without cutting it, including for gene regulation and epigenome editing.
OpenAlex ID: keywords/dcas9
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
2013 · Lei S. Qi, Matthew H. Larson, et al. · Cell · 5,005
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CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 · Luke A. Gilbert, Matthew H. Larson, et al. · Cell · 3,692
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Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
2015 · Isaac B Hilton, Anthony M D'Ippolito, et al. · Nature Biotechnology · 1,894
Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems
2016 · Keiji Nishida, Takayuki Arazoe, et al. · Science · 1,348
CRISPR RNA–guided activation of endogenous human genes
2013 · Morgan L Maeder, Samantha J Linder, et al. · Nature Methods · 1,248
Editing DNA Methylation in the Mammalian Genome
2016 · X. Shawn Liu, Hao Wu, et al. · Cell · 1,220
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Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
2014 · Xuebing Wu, David A Scott, et al. · Nature Biotechnology · 944
Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds
2014 · Jesse G. Zalatan, Michael E. Lee, et al. · Cell · 938
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Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation
2015 · Antonia A. Dominguez, Wendell A. Lim, et al. · Nature Reviews Molecular Cell Biology · 830
Repurposing the CRISPR-Cas9 system for targeted DNA methylation
2016 · Aleksandar Vojta, Paula Dobrinić, et al. · Nucleic Acids Research · 780
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Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
2014 · Cem Kuscu, Sevki Arslan, et al. · Nature Biotechnology · 775
Functional annotation of native enhancers with a Cas9–histone demethylase fusion
2015 · Nicola A Kearns, Hannah Pham, et al. · Nature Methods · 656
A light-inducible CRISPR-Cas9 system for control of endogenous gene activation
2015 · Lauren R Polstein, Charles A Gersbach · Nature Chemical Biology · 638
Comparison of Cas9 activators in multiple species
2016 · Alejandro Chavez, Marcelle Tuttle, et al. · Nature Methods · 522
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Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions
2016 · Sumiyo Morita, Hirofumi Noguchi, et al. · Nature Biotechnology · 503
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells
2016 · Gaelen T Hess, Laure Frésard, et al. · Nature Methods · 478
Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow
2016 · Hanhui Ma, Li-Chun Tu, et al. · Nature Biotechnology · 472
Latest Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing
2020 · Muhammad Naeem, Saman Majeed, et al. · Cells · 455
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CRISPR-Cas9 Based Engineering of Actinomycetal Genomes
2015 · Yaojun Tong, Pep Charusanti, et al. · ACS Synthetic Biology · 434
Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells
2016 · Yunqing Ma, Jiayuan Zhang, et al. · Nature Methods · 419
Nucleosomes impede Cas9 access to DNA in vivo and in vitro
2016 · Max A Horlbeck, Lea B Witkowsky, et al. · eLife · 418
Multicolor CRISPR labeling of chromosomal loci in human cells
2015 · Hanhui Ma, Ardalan Naseri, et al. · Proceedings of the National Academy of Sciences · 412
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Site-specific manipulation of Arabidopsis loci using CRISPR-Cas9 SunTag systems
2019 · Ashot Papikian, Wanlu Liu, et al. · Nature Communications · 401
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RNA‐guided transcriptional regulation in planta via synthetic dC as9‐based transcription factors
2014 · Agnieszka Piatek, Zahir Ali, et al. · Plant Biotechnology Journal · 386
A CRISPR-based approach for targeted DNA demethylation
2016 · Xingxing Xu, Yonghui Tao, et al. · Cell Discovery · 379
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Works count: 1,409
Citation count: 52,240
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