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dFOXO
Description:
A Drosophila transcription factor in the FOXO family that regulates processes including stress responses, metabolism, and aging.
Primary topic:
Genetics, Aging, and Longevity in Model Organisms (39%)
Related topics:
Genetics, Aging, and Longevity in Model Organisms (39%),
FOXO transcription factor regulation (26%),
Neurobiology and Insect Physiology Research (8%)
OpenAlex ID:
keywords/dfoxo
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
2004
·
Dae Sung Hwangbo
, Boris Gersham
, et al.
·
Nature
·
951
Antagonistic Actions of Ecdysone and Insulins Determine Final Size in Drosophila
2005
·
Julien Colombani
, Laurence Bianchini
, et al.
·
Science
·
618
The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
2003
·
Martin A Jünger
, Felix Rintelen
, et al.
·
Journal of Biology
·
601
PDF
Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body
2004
·
Maria E. Giannakou
, Martin Goss
, et al.
·
Science
·
577
PDF
Transcriptional feedback control of insulin receptor by dFOXO/FOXO1
2005
·
Oscar Puig
, Robert Tjian
·
Genes & Development
·
360
PDF
Insulin regulation of heart function in aging fruit flies
2004
·
Robert J Wessells
, Erin Fitzgerald
, et al.
·
Nature Genetics
·
324
Drosophila insulin‐like peptide‐6 ( dilp6 ) expression from fat body extends lifespan and represses secretion of Drosophila insulin‐like peptide‐2 from the brain
2012
·
Hua Bai
, Ping Kang
, et al.
·
Aging Cell
·
257
Expressionof Drosophila FOXO regulates growth and can phenocopy starvation
2003
·
Jamie M Kramer
, Jason T Davidge
, et al.
·
BMC Developmental Biology
·
226
PDF
Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster : not required, but its activity modulates the response
2007
·
Maria E. Giannakou
, Martin Goss
, et al.
·
Aging Cell
·
217
Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila
2013
·
Hua Bai
, Ping Kang
, et al.
·
PLoS Genetics
·
213
PDF
dFOXO‐independent effects of reduced insulin‐like signaling in Drosophila
2011
·
Cathy Slack
, Maria E. Giannakou
, et al.
·
Aging Cell
·
204
PDF
Reduction of DILP2 in Drosophila Triages a Metabolic Phenotype from Lifespan Revealing Redundancy and Compensation among DILPs
2008
·
Susan Broughton
, Nazif Alic
, et al.
·
PLoS ONE
·
194
PDF
Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP
2005
·
Gritta Tettweiler
, Mathieu Miron
, et al.
·
Genes & Development
·
186
PDF
Drosophila lifespan control by dietary restriction independent of insulin‐like signaling
2008
·
Kyung‐Jin Min
, Rochele Yamamoto
, et al.
·
Aging Cell
·
183
PDF
High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO
2006
·
Boris Gershman
, Oscar Puig
, et al.
·
Physiological Genomics
·
175
Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila
2007
·
Hwei-Jan Hsu
, Leesa LaFever
, et al.
·
Developmental Biology
·
167
PDF
Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan
2015
·
Fumiaki Obata
, Masayuki Miura
·
Nature Communications
·
157
PDF
The Drosophila PGC‐1 homologue Spargel coordinates mitochondrial activity to insulin signalling
2009
·
Stefanie K Tiefenböck
, Claudia Baltzer
, et al.
·
The EMBO Journal
·
131
PDF
Genome‐wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling
2011
·
Nazif Alic
, T Daniel Andrews
, et al.
·
Molecular Systems Biology
·
128
Characterization of the Drosophila Gene‐Switch system in aging studies: a cautionary tale
2008
·
Luc Poirier
, Amanda Shane
, et al.
·
Aging Cell
·
118
PDF
dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner
2012
·
Kushal Kr. Banerjee
, Champakali Ayyub
, et al.
·
Cell Reports
·
113
PDF
Dynamics of the action of dFOXO on adult mortality in Drosophila
2007
·
Maria E. Giannakou
, Martin Goss
, et al.
·
Aging Cell
·
107
Insulin Signaling Mediates Sexual Attractiveness in Drosophila
2012
·
Tsung-Han Kuo
, Tatyana Y. Fedina
, et al.
·
PLoS Genetics
·
89
PDF
d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila
2009
·
Robert Wessells
, Erin Fitzgerald
, et al.
·
Aging Cell
·
89
Regulation of Lifespan, Metabolism, and Stress Responses by the Drosophila SH2B Protein, Lnk
2010
·
Cathy Slack
, Christian Werz
, et al.
·
PLoS Genetics
·
86
PDF
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Works count:
173
Citation count:
8,309
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