Keyword

entinostat

Description: Entinostat is a small-molecule histone deacetylase inhibitor studied as an anticancer drug, both alone and in combination therapies.

Primary topic: Histone Deacetylase Inhibitors Research (33%)

Wikidata ID: wiki/Q1281020

OpenAlex ID: keywords/entinostat

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

2009 · Chunaram Choudhary, Chanchal Kumar, et al. · Science · 4,033

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

2007 · Nagma Khan, Michael Jeffers, et al. · Biochemical Journal · 711

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Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non–Small Cell Lung Cancer

2011 · Rosalyn A. Juergens, John Wrangle, et al. · Cancer Discovery · 686

Antidepressant Actions of Histone Deacetylase Inhibitors

2009 · Herbert E. Covington, Ian Maze, et al. · Journal of Neuroscience · 622

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Restoring E-Cadherin Expression Increases Sensitivity to Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cell Lines

2006 · Samir E. Witta, Robert M. Gemmill, et al. · Cancer Research · 515

Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

2005 · J. S. Ungerstedt, Y. Sowa, et al. · Proceedings of the National Academy of Sciences · 504

Do biomedical models of illness make for good healthcare systems?

2004 · Derick T Wade, Peter W Halligan · BMJ · 471

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The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.

2003 · Roberto R Rosato, Jorge A Almenara, et al. · PubMed · 465

Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents

2010 · Jiahuai Tan, Shundong Cang, et al. · Journal of Hematology & Oncology · 425

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Randomized Phase II, Double-Blind, Placebo-Controlled Study of Exemestane With or Without Entinostat in Postmenopausal Women With Locally Recurrent or Metastatic Estrogen Receptor-Positive Breast Cancer Progressing on Treatment With a Nonsteroidal Aromatase Inhibitor

2013 · Denise A. Yardley, Roohi R. Ismail-Khan, et al. · Journal of Clinical Oncology · 423

Phase I and Pharmacokinetic Study of MS-275, a Histone Deacetylase Inhibitor, in Patients With Advanced and Refractory Solid Tumors or Lymphoma

2005 · Qin C. Ryan, Donna Headlee, et al. · Journal of Clinical Oncology · 411

Entinostat Neutralizes Myeloid-Derived Suppressor Cells and Enhances the Antitumor Effect of PD-1 Inhibition in Murine Models of Lung and Renal Cell Carcinoma

2017 · Ashley Orillion, Ayumi Hashimoto, et al. · Clinical Cancer Research · 373

Histone deacetylase inhibitors

2004 · Claude Monneret · European Journal of Medicinal Chemistry · 338

Epigenetic therapy inhibits metastases by disrupting premetastatic niches

2020 · Zhihao Lu, Jianling Zou, et al. · Nature · 329

MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

2009 · Maria E. Figueroa, Lucy Skrabanek, et al. · Blood · 325

Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression

2013 · Sam A Golden, Daniel J Christoffel, et al. · Nature Medicine · 322

Curcumin is an Inhibitor of p300 Histone Acetylatransferase

2006 · Len Neckers, Jane Trepel, et al. · Medicinal Chemistry · 311

Synthesis and Histone Deacetylase Inhibitory Activity of New Benzamide Derivatives

1999 · Tsuneji Suzuki, Tomoyuki Ando, et al. · Journal of Medicinal Chemistry · 293

Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies

2009 · Tamer E. Fandy, James G. Herman, et al. · Blood · 282

Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias

2006 · Ivana Gojo, Anchalee Jiemjit, et al. · Blood · 281

Epithelial to Mesenchymal Transition in an Epidermal Growth Factor Receptor-Mutant Lung Cancer Cell Line with Acquired Resistance to Erlotinib

2011 · Kenichi Suda, Kenji Tomizawa, et al. · Journal of Thoracic Oncology · 276

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Anti‐rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen‐induced arthritis in rodents

2007 · H‐S Lin, C‐Y Hu, et al. · British Journal of Pharmacology · 272

Prolonged Administration of Azacitidine With or Without Entinostat for Myelodysplastic Syndrome and Acute Myeloid Leukemia With Myelodysplasia-Related Changes: Results of the US Leukemia Intergroup Trial E1905

2014 · Thomas Prebet, Zhuoxin Sun, et al. · Journal of Clinical Oncology · 247

Blockade of Histone Deacetylase Inhibitor-Induced RelA/p65 Acetylation and NF-κB Activation Potentiates Apoptosis in Leukemia Cells through a Process Mediated by Oxidative Damage, XIAP Downregulation, and c-Jun N-Terminal Kinase 1 Activation

2005 · Yun Dai, Mohamed Rahmani, et al. · Molecular and Cellular Biology · 245

Histone Acetylation-independent Effect of Histone Deacetylase Inhibitors on Akt through the Reshuffling of Protein Phosphatase 1 Complexes

2005 · Chang-Shi Chen, Chang-Shi Chen, et al. · Journal of Biological Chemistry · 231

Works count: 1,983

Citation count: 46,560