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epothilones
Description:
A class of natural-product compounds that stabilize microtubules and are investigated as anticancer drugs.
Primary topic:
Cancer Treatment and Pharmacology (25%)
Related topics:
Cancer Treatment and Pharmacology (25%),
Microtubule and mitosis dynamics (14%),
Microbial Natural Products and Biosynthesis (14%)
Wikidata ID:
wiki/Q408201
OpenAlex ID:
keywords/epothilones
Handbook of Metathesis
2003
·
Wiley eBooks
·
1,671
Mechanisms of Chemotherapy-Induced Peripheral Neuropathy
2019
·
Renata Zajączkowska
, Magdalena Kocot-Kępska
, et al.
·
International Journal of Molecular Sciences
·
830
PDF
Mechanism of Action of Antitumor Drugs that Interact with Microtubules and Tubulin
2005
·
M. Jordan
·
Anti-Cancer Agents in Medicinal Chemistry
·
775
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.
1995
·
D M Bollag
, P A McQueney
, et al.
·
PubMed
·
688
Chemotherapy-induced peripheral neurotoxicity (CIPN): An update
2011
·
Andreas A. Argyriou
, Jordi Bruna
, et al.
·
Critical Reviews in Oncology/Hematology
·
569
Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance
2009
·
Edith A. Perez
·
Molecular Cancer Therapeutics
·
522
Synthesis of Medium-Sized Rings by the Ring-Closing Metathesis Reaction
2000
·
Martin E. Maier
·
Angewandte Chemie International Edition
·
508
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
2000
·
Paraskevi Giannakakou
, Rick Gussio
, et al.
·
Proceedings of the National Academy of Sciences
·
477
Peripheral Neuropathy Induced by Microtubule-Stabilizing Agents
2006
·
James J. Lee
, Sandra M. Swain
·
Journal of Clinical Oncology
·
472
Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC
2010
·
Alex Chang
·
Lung Cancer
·
443
Complete genome sequence of the myxobacterium Sorangium cellulosum
2007
·
Susanne Schneiker
, Olena Perlova
, et al.
·
Nature Biotechnology
·
425
PDF
Cloning and Heterologous Expression of the Epothilone Gene Cluster
2000
·
Li Tang
, Sanjay Shah
, et al.
·
Science
·
424
Pharmacological Strategies for Overcoming Multidrug Resistance
2006
·
S. Nobili
, I. Landini
, et al.
·
Current Drug Targets
·
394
Thiazole-containing compounds as therapeutic targets for cancer therapy
2019
·
Prabodh Chander Sharma
, Kushal Kumar Bansal
, et al.
·
European Journal of Medicinal Chemistry
·
382
Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer
2008
·
Helen M. Coley
·
Cancer Treatment Reviews
·
351
Epothilones: Mechanism of Action and Biologic Activity
2004
·
Susan Goodin
, Michael P. Kane
, et al.
·
Journal of Clinical Oncology
·
348
Myxobacteria: proficient producers of novel natural products with various biological activities—past and future biotechnological aspects with the focus on the genus Sorangium
2003
·
Klaus Gerth
, Silke Pradella
, et al.
·
Journal of Biotechnology
·
330
Chemical Biology of Epothilones
1998
·
K. C. Nicolaou
, Frank Roschangar
, et al.
·
Angewandte Chemie International Edition
·
329
Tubulin-Interactive Natural Products as Anticancer Agents
2009
·
David G. I. Kingston
·
Journal of Natural Products
·
328
Review: Tubulin Function, Action of Antitubulin Drugs, and New Drug Development
2005
·
Federico Pellegrini
, Daniel R Budman
·
Cancer Investigation
·
314
The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90
2000
·
I Molnár
, T Schupp
, et al.
·
Chemistry & Biology
·
297
PDF
Enzymatic Chemistry of Cyclopropane, Epoxide, and Aziridine Biosynthesis
2011
·
Christopher J. Thibodeaux
, Wei-chen Chang
, et al.
·
Chemical Reviews
·
275
Update on taxane development: new analogs and new formulations
2012
·
Katherine Tkaczuk
, Jean Yared
·
Drug Design Development and Therapy
·
252
PDF
A common pharmacophore for cytotoxic natural products that stabilize microtubules
1999
·
Iwao Ojima
, Subrata Chakravarty
, et al.
·
Proceedings of the National Academy of Sciences
·
250
Microtubule dynamics as a target in oncology
2008
·
April L. Risinger
, Francis J. Giles
, et al.
·
Cancer Treatment Reviews
·
248
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Works count:
984
Citation count:
33,190
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