Keyword

FKBP

Description: FKBPs are a family of immunophilin proteins with peptidyl-prolyl cis-trans isomerase activity, involved in protein folding and cellular signaling.

Primary topic: Signaling Pathways in Disease (32%)

Wikidata ID: wiki/Q583864

OpenAlex ID: keywords/fkbp

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 · Jun Liu, Jesse D. Farmer, et al. · Cell · 4,104

Discovering High-Affinity Ligands for Proteins: SAR by NMR

1996 · Suzanne B. Shuker, Philip J. Hajduk, et al. · Science · 2,042

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 · Neil A. Clipstone, Gerald R. Crabtree · Nature · 1,638

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

1989 · Matthew W. Harding, Andrzej Galat, et al. · Nature · 1,396

Calcineurin: Form and Function

2000 · Frank Rusnak, Pamela Mertz · Physiological Reviews · 1,375

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 · Jongkyeong Chung, Calvin J. Kuo, et al. · Cell · 1,150

Anatomy of protein pockets and cavities: Measurement of binding site geometry and implications for ligand design

1998 · Jie Liang, Clare Woodward, et al. · Protein Science · 1,057

PDF

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 · John J. Siekierka, Shirley H. Y. Hung, et al. · Nature · 1,010

Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism

1997 · Michael B. Yaffe, Mike Schutkowski, et al. · Science · 770

An inducible caspase 9 safety switch for T-cell therapy

2005 · Karin C. Straathof, Martin A. Pulè, et al. · Blood · 743

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 · B E Bierer, P S Mattila, et al. · Proceedings of the National Academy of Sciences · 696

The Mechanism of Action of Cyclosporin A and FK506

1996 · Steffan Ho, Neil Clipstone, et al. · Clinical Immunology and Immunopathology · 677

PDF

Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

1992 · N H Sigal, F J Dumont · Annual Review of Immunology · 669

Immunopharmacology of Rapamycin

1996 · Robert T. Abraham, Gregory J. Wiederrecht · Annual Review of Immunology · 653

Prolyl cis-trans isomerization as a molecular timer

2007 · Kun Ping Lu, Greg Finn, et al. · Nature Chemical Biology · 652

Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts

1999 · S. F. G�thel, M. A. Marahiel · Cellular and Molecular Life Sciences · 647

Atomic Structure of FKBP-FK506, an Immunophilin-Immunosuppressant Complex

1991 · Gregory D. Van Duyne, Robert F. Standaert, et al. · Science · 635

Rapamycin-FKBP Inhibits Cell Cycle Regulators of Proliferation in Vascular Smooth Muscle Cells

1995 · Steven O. Marx, Thottala Jayaraman, et al. · Circulation Research · 600

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1992 · Calvin J. Kuo, Jongkyeong Chung, et al. · Nature · 595

Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

1998 · Tim Clackson, Wu Yang, et al. · Proceedings of the National Academy of Sciences · 556

FK506 binding protein associated with the calcium release channel (ryanodine receptor).

1992 · T Jayaraman, A.M. Brillantes, et al. · Journal of Biological Chemistry · 526

Kinetics of regulated protein–protein interactions revealed with firefly luciferase complementation imaging in cells and living animals

2004 · Kathryn E. Luker, Matthew C. P. Smith, et al. · Proceedings of the National Academy of Sciences · 439

Mode of Action of Tacrolimus (FK506): Molecular and Cellular Mechanisms

1995 · A. W. Thomson, C. A. Bonham, et al. · Therapeutic Drug Monitoring · 439

FKBP8 recruits LC3A to mediate Parkin‐independent mitophagy

2017 · Zambarlal Bhujabal, Åsa B Birgisdottir, et al. · EMBO Reports · 421

PDF

Ligand-dependent Interaction of the Aryl Hydrocarbon Receptor with a Novel Immunophilin Homolog in Vivo

1997 · Lucy A. Carver, Christopher A. Bradfield · Journal of Biological Chemistry · 416

PDF

Works count: 1,523

Citation count: 74,440