Keyword

FLT3 mutation

Description: A genetic alteration in the FLT3 gene, studied particularly for its role in blood cancers such as acute myeloid leukemia.

Primary topic: Acute Myeloid Leukemia Research (85%)

OpenAlex ID: keywords/flt3-mutation

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

2017 · Richard M. Stone, Sumithra J. Mandrekar, et al. · New England Journal of Medicine · 2,230

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DNMT3A Mutations in Acute Myeloid Leukemia

2010 · Timothy J. Ley, Li Ding, et al. · New England Journal of Medicine · 1,984

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Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

2002 · Christian Thiede, Christine Steudel, et al. · Blood · 1,735

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The roles of FLT3 in hematopoiesis and leukemia

2002 · D. Gary Gilliland, James D. Griffin · Blood · 1,559

Targeting FLT3 mutations in AML: review of current knowledge and evidence

2019 · Naval Daver, Richard F. Schlenk, et al. · Leukemia · 1,079

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Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm

2002 · Stefan Fröhling, Richard F. Schlenk, et al. · Blood · 872

Molecular International Prognostic Scoring System for Myelodysplastic Syndromes

2022 · Elsa Bernard, Heinz Tuechler, et al. · NEJM Evidence · 863

The role of FLT3 in haematopoietic malignancies

2003 · Derek L. Stirewalt, Jerald P. Radich · Nature reviews. Cancer · 862

The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

2017 · Hamid Bolouri, Jason E Farrar, et al. · Nature Medicine · 850

Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

2005 · Susanne Schnittger, Claudia Schoch, et al. · Blood · 713

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Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412

2004 · Richard M. Stone, Daniel J. DeAngelo, et al. · Blood · 658

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G Enetics of M Yeloid L Eukemias

2002 · Louise M. Kelly, D. Gary Gilliland · Annual Review of Genomics and Human Genetics · 523

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

2008 · Zhihong Zeng, Yue Xi Shi, et al. · Blood · 518

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Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3

2010 · Thomas Fischer, Richard M. Stone, et al. · Journal of Clinical Oncology · 501

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A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease

2005 · Walter Fiedler, Hubert Serve, et al. · Blood · 490

CEBPA Mutations in Younger Adults With Acute Myeloid Leukemia and Normal Cytogenetics: Prognostic Relevance and Analysis of Cooperating Mutations

2004 · Stefan Fröhling, Richard F. Schlenk, et al. · Journal of Clinical Oncology · 459

Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia

2019 · Christine M. McMahon, Timothy Ferng, et al. · Cancer Discovery · 441

FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia

2001 · Derek L. Stirewalt, Kenneth J. Kopecky, et al. · Blood · 431

Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

2009 · Jiong Hu, Yuan-Fang Liu, et al. · Proceedings of the National Academy of Sciences · 425

A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy

2006 · Steven Knapper, Alan K. Burnett, et al. · Blood · 413

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Prognostic Significance of the European LeukemiaNet Standardized System for Reporting Cytogenetic and Molecular Alterations in Adults With Acute Myeloid Leukemia

2012 · Krzysztof Mrózek, Guido Marcucci, et al. · Journal of Clinical Oncology · 406

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Inhibition of FLT3 in MLL

2003 · Scott A Armstrong, Andrew L Kung, et al. · Cancer Cell · 399

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Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse

2011 · Mark Levis, Farhad Ravandi, et al. · Blood · 398

Clinical implications of FLT3 mutations in pediatric AML

2006 · S. Meshinchi, T. A. Alonzo, et al. · Blood · 397

Identification of novel FLT‐3 Asp835 mutations in adult acute myeloid leukaemia

2001 · F. M. Abu‐Duhier, A. C. Goodeve, et al. · British Journal of Haematology · 388

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Works count: 3,392

Citation count: 72,110