Keyword

fMLP

Description: A formylated tripeptide that acts as a chemoattractant, commonly studied in research on neutrophil activation and immune responses.

Primary topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms (31%)

Wikidata ID: wiki/Q5090627

OpenAlex ID: keywords/fmlp

A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture

1980 · Edgar Pick, Yona Keisari · Journal of Immunological Methods · 1,217

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 · A Arcaro, M P Wymann · Biochemical Journal · 1,140

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Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.

1989 · C W Smith, S D Marlin, et al. · Journal of Clinical Investigation · 1,092

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ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).

1990 · M S Diamond, D E Staunton, et al. · The Journal of Cell Biology · 881

Stimulation of neutrophils by tumor necrosis factor.

1986 · S J Klebanoff, M A Vadas, et al. · The Journal of Immunology · 832

Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

1987 · C F Nathan · Journal of Clinical Investigation · 797

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Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide.

1985 · C Haslett, L A Guthrie, et al. · PubMed · 779

Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance

2017 · Giang T. Nguyen, Erin R. Green, et al. · Frontiers in Cellular and Infection Microbiology · 740

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Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival.

1986 · A F Lopez, D J Williamson, et al. · Journal of Clinical Investigation · 707

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Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

1992 · R M Clancy, J Leszczynska-Piziak, et al. · Journal of Clinical Investigation · 686

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A novel neutrophil-activating factor produced by human mononuclear phagocytes.

1988 · P Peveri, A Walz, et al. · The Journal of Experimental Medicine · 647

Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme.

1984 · L A Guthrie, L C McPhail, et al. · The Journal of Experimental Medicine · 616

Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties.

1998 · S Sozzani, P Allavena, et al. · PubMed · 605

Mechanics of Stimulated Neutrophils: Cell Stiffening Induces Retention in Capillaries

1989 · G. Scott Worthen, Bill Schwab, et al. · Science · 597

Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness.

1990 · R J Smith, L M Sam, et al. · Journal of Pharmacology and Experimental Therapeutics · 569

Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.

1986 · L A Smedly, M G Tonnesen, et al. · Journal of Clinical Investigation · 567

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A microplate assay for the detection of oxidative products using 2′,7′-dichlorofluorescin-diacetate

1992 · Alexander R. Rosenkranz, Sabine Schmaldienst, et al. · Journal of Immunological Methods · 539

Human granulocyte-macrophage colony-stimulating factor is a neutrophil activator

1985 · Richard H. Weisbart, David W. Golde, et al. · Nature · 538

A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo

1987 · KE Arfors, C Lundberg, et al. · Blood · 524

Cutting Edge: Differential Regulation of Chemokine Receptors During Dendritic Cell Maturation: A Model for Their Trafficking Properties

1998 · Silvano Sozzani, Paola Allavena, et al. · The Journal of Immunology · 507

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Glucocorticoid treatment inhibits apoptosis in human neutrophils. Separation of survival and activation outcomes.

1995 · G Cox · The Journal of Immunology · 505

Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants.

1989 · T Yoshimura, E A Robinson, et al. · The Journal of Experimental Medicine · 490

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Monocyte-chemotactic activity of defensins from human neutrophils.

1989 · M C Territo, T Ganz, et al. · Journal of Clinical Investigation · 489

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An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients

2002 · Bryan Heit, Samantha Tavener, et al. · The Journal of Cell Biology · 486

Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration

1986 · V. von Tscharner, B. Prod'hom, et al. · Nature · 481

Works count: 6,775

Citation count: 229,000