Keyword

FOLFOX4

Description: FOLFOX4 is a specific schedule of combination chemotherapy using folinic acid, fluorouracil, and oxaliplatin, primarily used to treat colorectal cancer.

Primary topic: Colorectal Cancer Treatments and Studies (56%)

OpenAlex ID: keywords/folfox4

Bevacizumab in Combination With Oxaliplatin-Based Chemotherapy As First-Line Therapy in Metastatic Colorectal Cancer: A Randomized Phase III Study

2008 · Leonard B. Saltz, Stephen Clarke, et al. · Journal of Clinical Oncology · 2,956

Bevacizumab in Combination With Oxaliplatin, Fluorouracil, and Leucovorin (FOLFOX4) for Previously Treated Metastatic Colorectal Cancer: Results From the Eastern Cooperative Oncology Group Study E3200

2007 · Bruce J. Giantonio, Paul J. Catalano, et al. · Journal of Clinical Oncology · 2,283

Improved Overall Survival With Oxaliplatin, Fluorouracil, and Leucovorin As Adjuvant Treatment in Stage II or III Colon Cancer in the MOSAIC Trial

2009 · Thierry André, Corrado Boni, et al. · Journal of Clinical Oncology · 2,279

Panitumumab–FOLFOX4 Treatment and RAS Mutations in Colorectal Cancer

2013 · Jean-Yves Douillard, Kelly S. Oliner, et al. · New England Journal of Medicine · 2,262

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Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial

2008 · Bernard Nordlinger, Halfdan Sorbye, et al. · The Lancet · 1,937

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Randomized, Phase III Trial of Panitumumab With Infusional Fluorouracil, Leucovorin, and Oxaliplatin (FOLFOX4) Versus FOLFOX4 Alone As First-Line Treatment in Patients With Previously Untreated Metastatic Colorectal Cancer: The PRIME Study

2010 · Jean-Yves Douillard, Salvatore Siena, et al. · Journal of Clinical Oncology · 1,809

Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial

2020 · Renu R Bahadoer, Esmée A Dijkstra, et al. · The Lancet Oncology · 1,698

Fluorouracil, Leucovorin, and Oxaliplatin With and Without Cetuximab in the First-Line Treatment of Metastatic Colorectal Cancer

2008 · Carsten Bokemeyer, Igor Bondarenko, et al. · Journal of Clinical Oncology · 1,637

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Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial

2013 · Bernard Nordlinger, Halfdan Sorbye, et al. · The Lancet Oncology · 1,306

Randomized Phase III Study of Capecitabine Plus Oxaliplatin Compared With Fluorouracil/Folinic Acid Plus Oxaliplatin As First-Line Therapy for Metastatic Colorectal Cancer

2008 · Jim Cassidy, Stephen Clarke, et al. · Journal of Clinical Oncology · 862

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OPTIMOX1: A Randomized Study of FOLFOX4 or FOLFOX7 With Oxaliplatin in a Stop-and-Go Fashion in Advanced Colorectal Cancer—A GERCOR Study

2006 · Christophe Tournigand, Andres Cervantes, et al. · Journal of Clinical Oncology · 805

Phase III Randomized Trial of FOLFIRI Versus FOLFOX4 in the Treatment of Advanced Colorectal Cancer: A Multicenter Study of the Gruppo Oncologico Dell’Italia Meridionale

2005 · Giuseppe Colucci, Vittorio Gebbia, et al. · Journal of Clinical Oncology · 779

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study

2011 · C. Bokemeyer, I. Bondarenko, et al. · Annals of Oncology · 775

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Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: Updated 10-Year Survival and Outcomes According to BRAF Mutation and Mismatch Repair Status of the MOSAIC Study

2015 · Thierry André, Armand de Gramont, et al. · Journal of Clinical Oncology · 681

Superiority of Oxaliplatin and Fluorouracil-Leucovorin Compared With Either Therapy Alone in Patients With Progressive Colorectal Cancer After Irinotecan and Fluorouracil-Leucovorin: Interim Results of a Phase III Trial

2003 · Mace L. Rothenberg, Amit M. Oza, et al. · Journal of Clinical Oncology · 646

Final results from PRIME: randomized phase III study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer

2014 · J.Y. Douillard, S. Siena, et al. · Annals of Oncology · 607

Oxaliplatin, Fluorouracil, and Leucovorin for Patients With Unresectable Liver-Only Metastases From Colorectal Cancer: A North Central Cancer Treatment Group Phase II Study

2005 · Steven R. Alberts, William L. Horvath, et al. · Journal of Clinical Oncology · 537

Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial

2012 · Aimery de Gramont, Eric Van Cutsem, et al. · The Lancet Oncology · 533

Randomized, Multicenter, Open-Label Study of Oxaliplatin Plus Fluorouracil/Leucovorin Versus Doxorubicin As Palliative Chemotherapy in Patients With Advanced Hepatocellular Carcinoma From Asia

2013 · Shukui Qin, Yuxian Bai, et al. · Journal of Clinical Oncology · 500

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Pooled Analysis of Safety and Efficacy of Oxaliplatin Plus Fluorouracil/Leucovorin Administered Bimonthly in Elderly Patients With Colorectal Cancer

2006 · Richard M. Goldberg, Isabelle Tabah-Fisch, et al. · Journal of Clinical Oncology · 469

Long-course oxaliplatin-based preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer: results of a randomized phase III study

2016 · K. Bujko, L. Wyrwicz, et al. · Annals of Oncology · 439

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Adjuvant Therapy With Fluorouracil and Oxaliplatin in Stage II and Elderly Patients (between ages 70 and 75 years) With Colon Cancer: Subgroup Analyses of the Multicenter International Study of Oxaliplatin, Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer Trial

2012 · Christophe Tournigand, Thierry André, et al. · Journal of Clinical Oncology · 389

High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group (ECOG) study E3200

2005 · B. J. Giantonio, P. J. Catalano, et al. · Journal of Clinical Oncology · 344

Phase II Trial of Cetuximab in Combination With Fluorouracil, Leucovorin, and Oxaliplatin in the First-Line Treatment of Metastatic Colorectal Cancer

2007 · Josep Tabernero, Eric Van Cutsem, et al. · Journal of Clinical Oncology · 338

Long-course preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study

2019 · B. Ciseł, L. Pietrzak, et al. · Annals of Oncology · 320

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Works count: 1,786

Citation count: 46,550