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FRS2
Description:
FRS2, or fibroblast growth factor receptor substrate 2, is an intracellular adaptor protein that transmits signals from receptor tyrosine kinases.
Primary topic:
Fibroblast Growth Factor Research (29%)
Related topics:
Fibroblast Growth Factor Research (29%),
Sarcoma Diagnosis and Treatment (9%)
OpenAlex ID:
keywords/frs2
A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway
1997
·
H Kouhara
, Y.R Hadari
, et al.
·
Cell
·
873
PDF
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
2002
·
Hiroshi Hanafusa
, Satoru Torii
, et al.
·
Nature Cell Biology
·
566
Antitumor Activity of Lenvatinib (E7080): An Angiogenesis Inhibitor That Targets Multiple Receptor Tyrosine Kinases in Preclinical Human Thyroid Cancer Models
2014
·
Osamu Tohyama
, Junji Matsui
, et al.
·
Journal of Thyroid Research
·
475
PDF
Identification of the Mechanisms Regulating the Differential Activation of the MAPK Cascade by Epidermal Growth Factor and Nerve Growth Factor in PC12 Cells
2001
·
Shih-chu Kao
, Rama K. Jaiswal
, et al.
·
Journal of Biological Chemistry
·
381
FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors
2000
·
S. H. Ong
, G. R. Guy
, et al.
·
Molecular and Cellular Biology
·
363
Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation
1998
·
Y. R. Hadari
, H. Kouhara
, et al.
·
Molecular and Cellular Biology
·
324
PDF
Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
2001
·
S. H. Ong
, Y. R. Hadari
, et al.
·
Proceedings of the National Academy of Sciences
·
314
N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling
2001
·
Ugo Cavallaro
, Joachim Niedermeyer
, et al.
·
Nature Cell Biology
·
307
Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
2008
·
Noriko Gotoh
·
Cancer Science
·
268
Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models
2018
·
Masahiro Matsuki
, Taisuke Hoshi
, et al.
·
Cancer Medicine
·
266
PDF
Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models
2007
·
L R Desnoyers
, R Pai
, et al.
·
Oncogene
·
264
Fibroblast Growth Factor (FGF) and FGF Receptor-Mediated Autocrine Signaling in Non-Small-Cell Lung Cancer Cells
2008
·
Lindsay Marek
, Kathryn E. Ware
, et al.
·
Molecular Pharmacology
·
224
Molecular Mechanisms of RET Activation in Human Cancer
2002
·
MASSIMO SANTORO
, ROSA MARINA MELILLO
, et al.
·
Annals of the New York Academy of Sciences
·
172
Development of transcriptomic biomarker signature in human saliva to detect lung cancer
2012
·
Lei Zhang
, Hua Xiao
, et al.
·
Cellular and Molecular Life Sciences
·
162
Sef Inhibits Fibroblast Growth Factor Signaling by Inhibiting FGFR1 Tyrosine Phosphorylation and Subsequent ERK Activation
2003
·
Dmitry Kovalenko
, Xuehui Yang
, et al.
·
Journal of Biological Chemistry
·
153
Docking Protein FRS2 Links the Protein Tyrosine Kinase RET and Its Oncogenic Forms with the Mitogen-Activated Protein Kinase Signaling Cascade
2001
·
R. M. Melillo
, M. Santoro
, et al.
·
Molecular and Cellular Biology
·
141
AZD2171 Shows Potent Antitumor Activity Against Gastric Cancer Over-Expressing Fibroblast Growth Factor Receptor 2/Keratinocyte Growth Factor Receptor
2007
·
Masayuki Takeda
, Tokuzo Arao
, et al.
·
Clinical Cancer Research
·
136
Identification of Druggable Cancer Driver Genes Amplified across TCGA Datasets
2014
·
Ying Chen
, Jeremy McGee
, et al.
·
PLoS ONE
·
133
PDF
Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development
2006
·
Renée V. Hoch
, Philippe Soriano
·
Development
·
120
Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation
1999
·
Peter Klint
, Shigeru Kanda
, et al.
·
Oncogene
·
120
Genomic Association Analysis Suggests Chromosome 12 Locus Influencing Antihypertensive Response to Thiazide Diuretic
2008
·
Stephen T. Turner
, Kent R. Bailey
, et al.
·
Hypertension
·
114
TrkB regulates neocortex formation through the Shc/PLCγ‐mediated control of neuronal migration
2004
·
Diego L Medina
, Carla Sciarretta
, et al.
·
The EMBO Journal
·
109
PDF
Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors
2007
·
Emma Sandilands
, Shiva Akbarzadeh
, et al.
·
EMBO Reports
·
106
Thyroid Hormone Activates Fibroblast Growth Factor Receptor-1 in Bone
2003
·
David A. Stevens
, Clare B. Harvey
, et al.
·
Molecular Endocrinology
·
106
PDF
Amplification of FRS2 and Activation of FGFR/FRS2 Signaling Pathway in High-Grade Liposarcoma
2013
·
Keqiang Zhang
, Kevin Chu
, et al.
·
Cancer Research
·
98
PDF
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Works count:
431
Citation count:
11,300
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