Keyword

GCLC

Description: A human gene encoding the catalytic subunit of glutamate-cysteine ligase, an enzyme involved in glutathione synthesis and cellular antioxidant defense.

Primary topic: Genomics, phytochemicals, and oxidative stress (22%)

Wikidata ID: wiki/Q18026129

OpenAlex ID: keywords/gclc

Regulation of glutathione synthesis

2008 · Shelly C. Lu · Molecular Aspects of Medicine · 2,125

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

2004 · Jung H. Suh, Swapna V. Shenvi, et al. · Proceedings of the National Academy of Sciences · 772

Oxidative cell death in cancer: mechanisms and therapeutic opportunities

2024 · Xiaoqin An, Wenfeng Yu, et al. · Cell Death and Disease · 528

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Glutathione Primes T Cell Metabolism for Inflammation

2017 · Tak W. Mak, Melanie Grusdat, et al. · Immunity · 510

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Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis

2020 · Yun Pyo Kang, Andrea Mockabee-Macias, et al. · Cell Metabolism · 351

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Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor-E2–related factor-2 transcriptional pathway

2007 · Jonathan M. Maher, Matthew Z. Dieter, et al. · Hepatology · 315

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Impaired glutathione synthesis in schizophrenia: Convergent genetic and functional evidence

2007 · René Gysin, Rudolf Kraftsik, et al. · Proceedings of the National Academy of Sciences · 309

l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway

2018 · Mingcai Liang, Zhengxuan Wang, et al. · Food and Chemical Toxicology · 271

Nrf1 and Nrf2 Regulate Rat Glutamate-Cysteine Ligase Catalytic Subunit Transcription Indirectly via NF-κB and AP-1

2005 · Heping Yang, Nathaniel Magilnick, et al. · Molecular and Cellular Biology · 250

Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation

2022 · Yang Xu, Yuting Li, et al. · Redox Biology · 245

The ketogenic diet increases mitochondrial glutathione levels

2008 · Stuart G. Jarrett, Julie B. Milder, et al. · Journal of Neurochemistry · 244

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

2011 · Adam Lister, Taoufik Nedjadi, et al. · Molecular Cancer · 242

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Knockout of the Mouse Glutamate Cysteine Ligase Catalytic Subunit (Gclc) Gene: Embryonic Lethal When Homozygous, and Proposed Model for Moderate Glutathione Deficiency When Heterozygous

2000 · Timothy P. Dalton, Matthew Z. Dieter, et al. · Biochemical and Biophysical Research Communications · 240

PM2.5 induces Nrf2-mediated defense mechanisms against oxidative stress by activating PIK3/AKT signaling pathway in human lung alveolar epithelial A549 cells

2013 · Xiaobei Deng, Wei Rui, et al. · Cell Biology and Toxicology · 227

Age-Associated Vascular Oxidative Stress, Nrf2 Dysfunction, and NF- B Activation in the Nonhuman Primate Macaca mulatta

2011 · Z. Ungvari, L. Bailey-Downs, et al. · The Journals of Gerontology Series A · 226

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Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene

2006 · Valeska Vollrath, Ana M. Wielandt, et al. · Biochemical Journal · 225

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Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

2011 · Bing Wang, Xiaolei Zhu, et al. · Free Radical Biology and Medicine · 224

Transcription Factor Nrf2-Mediated Antioxidant Defense System in the Development of Diabetic Retinopathy

2013 · Qing Zhong, Manish Mishra, et al. · Investigative Ophthalmology & Visual Science · 222

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After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult

2010 · Florencia Arredondo, Carolina Echeverry, et al. · Free Radical Biology and Medicine · 220

Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging

2012 · Sarah J. Chapple, Richard C.M. Siow, et al. · The International Journal of Biochemistry & Cell Biology · 216

Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal, SH-SY5Y Cells

2012 · Madhusudhanan Narasimhan, Dhyanesh Patel, et al. · PLoS ONE · 199

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Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

2018 · Gaojian Lian, JN Rashida Gnanaprakasam, et al. · eLife · 196

Human glutamate cysteine ligase gene regulation through the electrophile response element

2004 · Dale A. Dickinson, Anna-Liisa Levonen, et al. · Free Radical Biology and Medicine · 196

Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1†

2005 · Pengfei Gong, Arthur I. Cederbaum · Hepatology · 182

Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity

2010 · Lauren M. Aleksunes, Michael J. Goedken, et al. · Journal of Pharmacology and Experimental Therapeutics · 178

Works count: 1,144

Citation count: 32,150