Keyword

Grb2

Description: Grb2 is an adaptor protein that links activated cell-surface receptors to intracellular signaling pathways, including pathways regulating cell growth.

Primary topic: Protein Kinase Regulation and GTPase Signaling (25%)

Wikidata ID: wiki/Q5514416

OpenAlex ID: keywords/grb2

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 · E.J. Lowenstein, R.J. Daly, et al. · Cell · 1,632

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Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 · David D. Schlaepfer, Steven K. Hanks, et al. · Nature · 1,595

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 · Henrik Daub, F. Ulrich Weiss, et al. · Nature · 1,476

LAT

1998 · Weiguo Zhang, Joanne Sloan-Lancaster, et al. · Cell · 1,268

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Signaling through focal adhesion kinase

1999 · David D Schlaepfer, Christof R Hauck, et al. · Progress in Biophysics and Molecular Biology · 1,177

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Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 · László Buday, Julian Downward · Cell · 1,080

Feedback between p21 and reactive oxygen production is necessary for cell senescence

2010 · João F Passos, Glyn Nelson, et al. · Molecular Systems Biology · 1,013

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 · Maria Rozakis-Adcock, Ross Fernley, et al. · Nature · 1,009

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 · M. Rozakis-Adcock, J. McGlade, et al. · Nature · 973

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 · Ivan Dikic, George Tokiwa, et al. · Nature · 954

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 · N. Li, A. Batzer, et al. · Nature · 952

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 · Simon J. Cook, Frank McCormick · Science · 922

CD28 and CTLA‐4 coreceptor expression and signal transduction

2009 · Christopher E. Rudd, Alison Taylor, et al. · Immunological Reviews · 898

Early Lineage Segregation between Epiblast and Primitive Endoderm in Mouse Blastocysts through the Grb2-MAPK Pathway

2006 · Claire Chazaud, Yojiro Yamanaka, et al. · Developmental Cell · 897

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Specific Motifs Recognized by the SH2 Domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

1994 · Z. Songyang, S. E. Shoelson, et al. · Molecular and Cellular Biology · 882

A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway

1997 · H Kouhara, Y.R Hadari, et al. · Cell · 873

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LAT Palmitoylation

1998 · Weiguo Zhang, Ronald P Trible, et al. · Immunity · 838

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Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 · Sibo Feng, James K. Chen, et al. · Science · 799

Activation of Downstream Signals by the Long Form of the Leptin Receptor

2000 · Alexander S. Banks, Sarah M. Davis, et al. · Journal of Biological Chemistry · 797

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Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 · Pierre Chardin, Jacques H. Camonis, et al. · Science · 797

Endocytosis and intracellular trafficking of ErbBs

2008 · Alexander Sorkin, Lai Kuan Goh · Experimental Cell Research · 756

Phosphotyrosine interactome of the ErbB‐receptor kinase family

2005 · Waltraud X Schulze, Lei Deng, et al. · Molecular Systems Biology · 752

The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression

1996 · Kishore K Wary, Fabrizio Mainiero, et al. · Cell · 731

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A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth

1998 · Kishore K Wary, Agnese Mariotti, et al. · Cell · 718

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The SH2/SH3 domain‐containing protein GRB2 interacts with tyrosine‐phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 · E.Y. Skolnik, C.H. Lee, et al. · The EMBO Journal · 694

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Works count: 3,805

Citation count: 199,400