Keyword

GRP78

Description: GRP78 is an endoplasmic-reticulum chaperone protein, also called BiP, involved in protein folding and cellular stress responses.

Primary topic: Endoplasmic Reticulum Stress and Disease (34%)

Wikidata ID: wiki/Q18027351

OpenAlex ID: keywords/grp78

A C-terminal signal prevents secretion of luminal ER proteins

1987 · Sean Munro, Hugh R.B. Pelham · Cell · 2,185

Hepatogastroenterology

2012 · Yong Liu, Zong-Guang Zhou, et al. · Hepatogastroenterology · 2,097

Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress

1999 · Kyosuke Haze, Hiderou Yoshida, et al. · Molecular Biology of the Cell · 2,073

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

2000 · Jin Ye, Robert B Rawson, et al. · Molecular Cell · 1,864

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An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

1986 · Sean Munro, Hugh R.B. Pelham · Cell · 1,449

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

1988 · Yasunori Kozutsumi, Mark Segal, et al. · Nature · 1,321

Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation

2007 · Naomi Hosogai, Atsunori Fukuhara, et al. · Diabetes · 1,256

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Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins

1998 · Hiderou Yoshida, Kyosuke Haze, et al. · Journal of Biological Chemistry · 1,229

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Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

2006 · Esther A. Obeng, Louise M. Carlson, et al. · Blood · 1,146

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The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress

2005 · Amy S. Lee · Methods · 993

GRP78 Induction in Cancer: Therapeutic and Prognostic Implications

2007 · Amy S. Lee · Cancer Research · 857

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

2007 · D. R. Laybutt, A. M. Preston, et al. · Diabetologia · 829

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Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 · Xiao‐Zhong Wang, Heather P. Harding, et al. · The EMBO Journal · 787

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Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

2006 · Yuren Wei, Dong Wang, et al. · American Journal of Physiology-Endocrinology and Metabolism · 737

ER chaperones in mammalian development and human diseases

2007 · Min Ni, Amy S. Lee · FEBS Letters · 735

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GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

2009 · Hélène L. Kammoun, Hervé Chabanon, et al. · Journal of Clinical Investigation · 733

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Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways

2001 · Geoff H. Werstuck, Steven R. Lentz, et al. · Journal of Clinical Investigation · 703

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Endoplasmic Reticulum Chaperone Protein GRP78 Protects Cells from Apoptosis Induced by Topoisomerase Inhibitors

2003 · Ramachandra K. Reddy, Changhui Mao, et al. · Journal of Biological Chemistry · 696

GRP78: A cell's response to stress

2019 · Ibrahim M. Ibrahim, Doaa H. Abdelmalek, et al. · Life Sciences · 648

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Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

2014 · Á González-Rodríguez, R Mayoral, et al. · Cell Death and Disease · 617

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Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response

2000 · Yan Wang, Jingshi Shen, et al. · Journal of Biological Chemistry · 616

Role of the Unfolded Protein Response Regulator GRP78/BiP in Development, Cancer, and Neurological Disorders

2009 · Miao Wang, Shiuan Wey, et al. · Antioxidants and Redox Signaling · 609

Stress Induction of GRP78/BiP and Its Role in Cancer

2006 · Jianze Li, Amy Lee · Current Molecular Medicine · 599

HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells

2017 · Shan Zhu, Qiuhong Zhang, et al. · Cancer Research · 574

Chronic Palmitate But Not Oleate Exposure Induces Endoplasmic Reticulum Stress, Which May Contribute to INS-1 Pancreatic β-Cell Apoptosis

2006 · Elizabeth Karaskov, Cameron Scott, et al. · Endocrinology · 573

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Works count: 11,710

Citation count: 303,500