Keyword

GRP94

Description: An endoplasmic-reticulum molecular chaperone protein, encoded by HSP90B1, involved in protein folding and cellular stress responses.

Primary topic: Endoplasmic Reticulum Stress and Disease (34%)

Wikidata ID: wiki/Q18032093

OpenAlex ID: keywords/grp94

A C-terminal signal prevents secretion of luminal ER proteins

1987 · Sean Munro, Hugh R.B. Pelham · Cell · 2,185

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

1988 · Yasunori Kozutsumi, Mark Segal, et al. · Nature · 1,321

Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins

1998 · Hiderou Yoshida, Kyosuke Haze, et al. · Journal of Biological Chemistry · 1,229

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The 90-kDa Molecular Chaperone Family

1998 · Péter Csermely, Tamás Schnaider, et al. · Pharmacology & Therapeutics · 1,029

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

2012 · B Luo, A S Lee · Oncogene · 560

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

2008 · John C. Christianson, Thomas A. Shaler, et al. · Nature Cell Biology · 508

Proteasome Inhibition Leads to a Heat-shock Response, Induction of Endoplasmic Reticulum Chaperones, and Thermotolerance

1997 · Kevin T. Bush, Alfred L. Goldberg, et al. · Journal of Biological Chemistry · 468

Polyubiquitination and Proteasomal Degradation of the p185c-B-2 Receptor Protein-tyrosine Kinase Induced by Geldanamycin

1996 · Edward G. Mimnaugh, Christine Chavany, et al. · Journal of Biological Chemistry · 466

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GRP78/BiP Is Required for Cell Proliferation and Protecting the Inner Cell Mass from Apoptosis during Early Mouse Embryonic Development

2006 · Shengzhan Luo, Changhui Mao, et al. · Molecular and Cellular Biology · 430

Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum

1994 · Jeffrey Melnick, Jeanne L. Dul, et al. · Nature · 417

GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum

2011 · Michal Marzec, Davide Eletto, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 415

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The Glucose-Regulated Proteins (GRP78 and GRP94): Functions, Gene Regulation, and Applications

1994 · Edward Little, Meera Ramakrishnan, et al. · Critical Reviews in Eukaryotic Gene Expression · 392

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

1998 · Melinda A. Loo, Timothy J. Jensen, et al. · The EMBO Journal · 374

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Endoplasmic Reticulum Chaperones GRP78 and Calreticulin Prevent Oxidative Stress, Ca2+ Disturbances, and Cell Death in Renal Epithelial Cells

1997 · Hong Liu, Russell C. Bowes, et al. · Journal of Biological Chemistry · 373

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Sensitivity of Mature ErbB2 to Geldanamycin Is Conferred by Its Kinase Domain and Is Mediated by the Chaperone Protein Hsp90

2001 · Wanping Xu, Edward Mimnaugh, et al. · Journal of Biological Chemistry · 353

Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells.

1992 · A.J. Dorner, L.C. Wasley, et al. · The EMBO Journal · 342

Palmitic and linoleic acids induce ER stress and apoptosis in hepatoma cells

2012 · Yong Zhang, Rongliang Xue, et al. · Lipids in Health and Disease · 336

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Endoplasmic Reticulum Stress Gene Induction and Protection From Ischemia/Reperfusion Injury in the Hearts of Transgenic Mice With a Tamoxifen-Regulated Form of ATF6

2006 · Joshua J. Martindale, Rayne Fernandez, et al. · Circulation Research · 325

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Role of the Cytosolic Chaperones Hsp70 and Hsp90 in Maturation of the Cardiac Potassium Channel hERG

2003 · Eckhard Ficker, Adrienne T. Dennis, et al. · Circulation Research · 323

Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules.

1991 · E Degen, D B Williams · The Journal of Cell Biology · 313

Activation of an Unfolded Protein Response during Differentiation of Antibody-secreting B Cells

2002 · Jennifer N. Gass, Nicole M. Gifford, et al. · Journal of Biological Chemistry · 304

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Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis

2014 · Genyuan Zhu, Amy S. Lee · Journal of Cellular Physiology · 300

ERp99, an abundant, conserved glycoprotein of the endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the 94-kDa glucose regulated protein (GRP94).

1987 · R A Mazzarella, M Green · Journal of Biological Chemistry · 290

Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation.

1993 · Z. Li, P.K. Srivastava · The EMBO Journal · 285

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Protein quality control in the ER: The recognition of misfolded proteins

2010 · Pekka Määttänen, Kalle Gehring, et al. · Seminars in Cell and Developmental Biology · 284

Works count: 1,757

Citation count: 63,880