Keyword

HDAC6

Description: Histone deacetylase 6 is an enzyme that removes acetyl groups from proteins and participates in cellular processes including protein regulation and stress responses.

Primary topic: Histone Deacetylase Inhibitors Research (44%)

OpenAlex ID: keywords/hdac6

HDAC6 is a microtubule-associated deacetylase

2002 · Charlotte Hubbert, Amaris Guardiola, et al. · Nature · 2,376

The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase

2003 · Brian J North, Brett L Marshall, et al. · Molecular Cell · 1,538

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The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress

2003 · Yoshiharu Kawaguchi, Jeffrey J Kovacs, et al. · Cell · 1,524

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HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor

2005 · Jeffrey J. Kovacs, Patrick J.M. Murphy, et al. · Molecular Cell · 1,144

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Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

2003 · Stephen J. Haggarty, Kathryn M. Koeller, et al. · Proceedings of the National Academy of Sciences · 1,059

HEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium

2007 · Elena N. Pugacheva, Sandra A. Jablonski, et al. · Cell · 890

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Histone Deacetylase 6 Inhibition Compensates for the Transport Deficit in Huntington's Disease by Increasing Tubulin Acetylation

2007 · Jim P. Dompierre, Juliette D. Godin, et al. · Journal of Neuroscience · 790

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Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

2010 · Kyle V. Butler, Jay Kalin, et al. · Journal of the American Chemical Society · 778

Three proteins define a class of human histone deacetylases related to yeast Hda1p

1999 · Christina M. Grozinger, Christian A. Hassig, et al. · Proceedings of the National Academy of Sciences · 764

HDAC6 controls autophagosome maturation essential for ubiquitin‐selective quality‐control autophagy

2010 · Joo‐Yong Lee, Hiroshi Koga, et al. · The EMBO Journal · 756

Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90

2005 · Purva Bali, Michael Pranpat, et al. · Journal of Biological Chemistry · 754

FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.

2002 · Ryohei Furumai, Akihisa Matsuyama, et al. · PubMed · 732

HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin

2007 · Xiaohong Zhang, Zhigang Yuan, et al. · Molecular Cell · 722

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HDAC6 and Microtubules Are Required for Autophagic Degradation of Aggregated Huntingtin

2005 · Atsushi Iwata, Brigit E. Riley, et al. · Journal of Biological Chemistry · 719

In vivo destabilization of dynamic microtubules by HDAC6‐mediated deacetylation

2002 · Akihisa Matsuyama, Tadahiro Shimazu, et al. · The EMBO Journal · 719

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Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

2011 · Marcus Bantscheff, Carsten Hopf, et al. · Nature Biotechnology · 656

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

2005 · Teru Hideshima, James E. Bradner, et al. · Proceedings of the National Academy of Sciences · 593

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Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

2008 · Yu Zhang, SoHee Kwon, et al. · Molecular and Cellular Biology · 554

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

2010 · Joo-Yong Lee, Yoshito Nagano, et al. · The Journal of Cell Biology · 520

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HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions

2008 · Agustín Valenzuela-Fernández, J. Román Cabrero, et al. · Trends in Cell Biology · 506

Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

2016 · Yang Hai, David W Christianson · Nature Chemical Biology · 491

Elongator Controls the Migration and Differentiation of Cortical Neurons through Acetylation of α-Tubulin

2009 · Catherine Creppe, Lina Malinouskaya, et al. · Cell · 471

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Histone Deacetylase Is a Target of Valproic Acid-Mediated Cellular Differentiation

2004 · Nadia Gurvich, Oxana M. Tsygankova, et al. · Cancer Research · 459

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HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

2011 · Constantin d'Ydewalle, Jyothsna Krishnan, et al. · Nature Medicine · 454

p300 Transcriptional Repression Is Mediated by SUMO Modification

2003 · David Girdwood, Donna Bumpass, et al. · Molecular Cell · 454

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Works count: 5,390

Citation count: 121,100