Keyword

HDAC8

Description: HDAC8 is a human histone deacetylase enzyme that regulates protein acetylation and is studied in cell development and disease.

Primary topic: Histone Deacetylase Inhibitors Research (49%)

Wikidata ID: wiki/Q18042128

OpenAlex ID: keywords/hdac8

Decreased Histone Deacetylase Activity in Chronic Obstructive Pulmonary Disease

2005 · Kazuhiro Ito, Misako Ito, et al. · New England Journal of Medicine · 970

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Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases

2004 · John R Somoza, Robert J Skene, et al. · Structure · 699

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Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

2004 · Alessandro Vannini, Cinzia Volpari, et al. · Proceedings of the National Academy of Sciences · 632

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

2012 · Matthew A. Deardorff, Masashige Bando, et al. · Nature · 573

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A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

2008 · S Balasubramanian, J Ramos, et al. · Leukemia · 452

Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

2008 · Ina Oehme, Hedwig E. Deubzer, et al. · Clinical Cancer Research · 394

Identification of Novel Isoform-Selective Inhibitors within Class I Histone Deacetylases

2003 · Erding Hu, Edward Dul, et al. · Journal of Pharmacology and Experimental Therapeutics · 348

Expression profile of class I histone deacetylases in human cancer tissues

2007 · Masamune Nakagawa, Yoshinao Oda, et al. · Oncology Reports · 341

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Cloning and Characterization of a Novel Human Class I Histone Deacetylase That Functions as a Transcription Repressor

2000 · Erding Hu, Zunxuan Chen, et al. · Journal of Biological Chemistry · 307

HDAC8: a multifaceted target for therapeutic interventions

2015 · Alokta Chakrabarti, Ina Oehme, et al. · Trends in Pharmacological Sciences · 275

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Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8–substrate complex

2007 · Alessandro Vannini, Cinzia Volpari, et al. · EMBO Reports · 255

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Epigenetic modulation of the renal β-adrenergic–WNK4 pathway in salt-sensitive hypertension

2011 · ShengYu Mu, Tatsuo Shimosawa, et al. · Nature Medicine · 236

Cornelia de Lange syndrome

2014 · M.I. Boyle, C. Jespersgaard, et al. · Clinical Genetics · 230

LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression

2006 · Hnin Thanda Aung, Kate Schroder, et al. · The FASEB Journal · 229

Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility

2019 · Ryan S. Stowers, Anna Shcherbina, et al. · Nature Biomedical Engineering · 227

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Isoform-specific histone deacetylase inhibitors: The next step?

2009 · Sriram Balasubramanian, Erik Verner, et al. · Cancer Letters · 222

Epigenetic control of skull morphogenesis by histone deacetylase 8

2009 · Michael Haberland, Mayssa H. Mokalled, et al. · Genes & Development · 219

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Toward Selective Histone Deacetylase Inhibitor Design: Homology Modeling, Docking Studies, and Molecular Dynamics Simulations of Human Class I Histone Deacetylases

2005 · Di-Fei Wang, Paul Helquist, et al. · Journal of Medicinal Chemistry · 208

Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-NHL cell line Raji proliferation

2005 · Hong-li Liu, Yan Chen, et al. · Acta Pharmacologica Sinica · 204

Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors,

2008 · Daniel P. Dowling, Stephanie L. Gantt, et al. · Biochemistry · 198

Histone deacetylase HDAC8 associates with smooth muscle α‐actin and is essential for smooth muscle cell contractility

2005 · David Waltregny, Wendy Glénisson, et al. · The FASEB Journal · 197

Cloning and characterization of a novel human histone deacetylase, HDAC8

2000 · Joseph J. BUGGY, Mindy L. SIDERIS, et al. · Biochemical Journal · 194

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Multiple roles of class I HDACs in proliferation, differentiation, and development

2012 · Nina Reichert, Mohamed-Amin Choukrallah, et al. · Cellular and Molecular Life Sciences · 193

Mutation Spectrum and Genotype-Phenotype Correlation in Cornelia de Lange Syndrome

2013 · Linda Mannini, Francesco Cucco, et al. · Human Mutation · 189

An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor α

2010 · Brian J. Wilson, Annie M. Tremblay, et al. · Molecular Endocrinology · 189

Works count: 1,449

Citation count: 32,980