Keyword

HE4

Description: HE4, also known as human epididymis protein 4, is a protein biomarker studied for cancer detection and risk assessment, especially in ovarian cancer.

Primary topic: Ovarian cancer diagnosis and treatment (58%)

Wikidata ID: wiki/Q18035358

OpenAlex ID: keywords/he4

A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass

2008 · Richard G. Moore, D. Scott McMeekin, et al. · Gynecologic Oncology · 875

Colonic epithelial cell diversity in health and inflammatory bowel disease

2019 · Kaushal Parikh, Agne Antanaviciute, et al. · Nature · 861

Ovarian Carcinoma Subtypes Are Different Diseases: Implications for Biomarker Studies

2008 · Martin Köbel, Steve E Kalloger, et al. · PLoS Medicine · 814

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The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma.

2003 · Ingegerd Hellström, John Raycraft, et al. · PubMed · 711

The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass

2007 · Richard G. Moore, Amy K. Brown, et al. · Gynecologic Oncology · 695

Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review

2019 · Vincent Dochez, Hélène Caillon, et al. · Journal of Ovarian Research · 578

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Human Epididymis Protein 4 (HE4) Is a Secreted Glycoprotein that Is Overexpressed by Serous and Endometrioid Ovarian Carcinomas

2005 · Ronny Drapkin, Hans Henning von Horsten, et al. · Cancer Research · 570

MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress

2014 · Mildred Felder, Arvinder Kapur, et al. · Molecular Cancer · 524

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New tumor markers: CA125 and beyond

2005 · R.C. BAST, D. BADGWELL, et al. · International Journal of Gynecological Cancer · 504

Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer.

2000 · C D Hough, C A Sherman-Baust, et al. · PubMed · 494

Selection of Potential Markers for Epithelial Ovarian Cancer with Gene Expression Arrays and Recursive Descent Partition Analysis

2004 · Karen H. Lu, Andrea P. Patterson, et al. · Clinical Cancer Research · 440

Comprehensive analysis of HE4 expression in normal and malignant human tissues

2006 · Mary T Galgano, Garret M Hampton, et al. · Modern Pathology · 437

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Comparative hybridization of an array of 21 500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas

1999 · Michèl Schummer, WaiLap V Ng, et al. · Gene · 402

A Major Human Epididymis-Specific cDNA Encodes a Protein with Sequence Homology to Extracellular Proteinase Inhibitors1

1991 · Christiane Kirchhoff, Inka Habben, et al. · Biology of Reproduction · 395

Potential markers that complement expression of CA125 in epithelial ovarian cancer

2005 · Daniel G. Rosen, Lin Wang, et al. · Gynecologic Oncology · 385

HE4 and CA125 as a diagnostic test in ovarian cancer: prospective validation of the Risk of Ovarian Malignancy Algorithm

2011 · T Van Gorp, I Cadron, et al. · British Journal of Cancer · 354

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Comparison of a novel multiple marker assay vs the Risk of Malignancy Index for the prediction of epithelial ovarian cancer in patients with a pelvic mass

2010 · Richard G. Moore, Moune Jabre-Raughley, et al. · American Journal of Obstetrics and Gynecology · 325

Evaluation of the Diagnostic Accuracy of the Risk of Ovarian Malignancy Algorithm in Women With a Pelvic Mass

2011 · Richard G. Moore, M. Craig Miller, et al. · Obstetrics and Gynecology · 308

Ovarian Cancer Biomarker Performance in Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Specimens

2011 · Daniel W. Cramer, Robert C. Bast, et al. · Cancer Prevention Research · 300

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Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts

2009 · K Huhtinen, P Suvitie, et al. · British Journal of Cancer · 297

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Molecular Biomarkers for the Early Detection of Ovarian Cancer

2022 · Ruiqian Zhang, Michelle K. Y. Siu, et al. · International Journal of Molecular Sciences · 284

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Development of a Multimarker Assay for Early Detection of Ovarian Cancer

2010 · Zoya Yurkovetsky, Steven Skates, et al. · Journal of Clinical Oncology · 274

Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis

2013 · Valerie S LeBleu, Yingqi Teng, et al. · Nature Medicine · 260

Clinical Use of Cancer Biomarkers in Epithelial Ovarian Cancer

2015 · György Sölétormos, Michael J. Duffy, et al. · International Journal of Gynecological Cancer · 255

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Evaluation of biomarker panels for early stage ovarian cancer detection and monitoring for disease recurrence

2008 · Laura J. Havrilesky, Clark M. Whitehead, et al. · Gynecologic Oncology · 233

Works count: 3,491

Citation count: 48,170