Keyword

HER3

Description: A cell-surface receptor tyrosine kinase encoded by ERBB3 that participates in signaling pathways involved in cancer and normal cell biology.

Primary topic: HER2/EGFR in Cancer Research (48%)

Related topic: HER2/EGFR in Cancer Research (48%)

Wikidata ID: wiki/Q17917132

OpenAlex ID: keywords/her3

MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

2007 · Jeffrey A. Engelman, Kreshnik Zejnullahu, et al. · Science · 4,485

ErbB‐2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

1997 · Diana Graus‐Porta, Roger R. Beerli, et al. · The EMBO Journal · 1,590

The ErbB/HER family of protein-tyrosine kinases and cancer

2013 · Robert Roskoski · Pharmacological Research · 1,356

Multiple essential functions of neuregulin in development

1995 · Dirk Meyer, Carmen Birchmeier · Nature · 1,262

Novel anticancer targets: revisiting ERBB2 and discovering ERBB3

2009 · José Baselga, Sandra M. Swain · Nature reviews. Cancer · 1,142

A Hierarchical Network of Interreceptor Interactions Determines Signal Transduction by Neu Differentiation Factor/Neuregulin and Epidermal Growth Factor

1996 · Eldad Tzahar, Hadassa Waterman, et al. · Molecular and Cellular Biology · 1,037

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AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

2011 · Sarat Chandarlapaty, Ayana Sawai, et al. · Cancer Cell · 962

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Recurrent R-spondin fusions in colon cancer

2012 · Somasekar Seshagiri, Eric W. Stawiski, et al. · Nature · 960

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The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

2003 · Thomas Holbro, Roger R. Beerli, et al. · Proceedings of the National Academy of Sciences · 950

A Five-Gene Signature and Clinical Outcome in Non–Small-Cell Lung Cancer

2007 · Hsuan-Yu Chen, Sung-Liang Yu, et al. · New England Journal of Medicine · 935

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Mapping the Genetic Architecture of Gene Expression in Human Liver

2008 · Eric E Schadt, Cliona Molony, et al. · PLoS Biology · 921

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The transcription factor Sox10 is a key regulator of peripheral glial development

2001 · Stefan Britsch, Derk E. Goerich, et al. · Genes & Development · 915

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Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

2002 · David B Agus, Robert W Akita, et al. · Cancer Cell · 873

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c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 · Gil Levkowitz, Hadassa Waterman, et al. · Genes & Development · 865

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Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941

2009 · Teemu T. Junttila, Robert W. Akita, et al. · Cancer Cell · 829

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Quantum dot ligands provide new insights into erbB/HER receptor–mediated signal transduction

2004 · Diane S Lidke, Peter Nagy, et al. · Nature Biotechnology · 828

Specificity within the EGF family/ErbB receptor family signaling network

1998 · David J. Riese, David F. Stern · BioEssays · 809

HER kinase inhibition in patients with HER2- and HER3-mutant cancers

2018 · David M. Hyman, Sarina A. Piha-Paul, et al. · Nature · 775

Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.

1996 · R. Pinkas‐Kramarski, L. Soussan, et al. · The EMBO Journal · 769

Endocytosis and intracellular trafficking of ErbBs

2008 · Alexander Sorkin, Lai Kuan Goh · Experimental Cell Research · 756

Phosphotyrosine interactome of the ErbB‐receptor kinase family

2005 · Waltraud X Schulze, Lei Deng, et al. · Molecular Systems Biology · 751

Biology of HER2 and Its Importance in Breast Cancer

2001 · Yosef Yarden · Oncology · 737

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

1989 · M H Kraus, W Issing, et al. · Proceedings of the National Academy of Sciences · 737

A quantitative protein interaction network for the ErbB receptors using protein microarrays

2005 · Richard B. Jones, Andrew Gordus, et al. · Nature · 727

The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand‐receptor interactions

1997 · Iris Alroy, Yosef Yarden · FEBS Letters · 714

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Works count: 7,347

Citation count: 195,800