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Keyword

human aging

Description: The biological changes that accumulate in humans with advancing age, studied across molecular, physiological, developmental, and evolutionary contexts.
Wikidata ID: wiki/Q332154
OpenAlex ID: keywords/human-aging
Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates
2012 · Gregory Hannum, Justin Guinney, et al. · Molecular Cell · 4,254
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Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome
2003 · Maria Eriksson, W. Ted Brown, et al. · Nature · 2,221
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Decline in skeletal muscle mitochondrial function with aging in humans
2005 · Kevin R. Short, Maureen L. Bigelow, et al. · Proceedings of the National Academy of Sciences · 1,327
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Human Aging, Muscle Mass, and Fiber Type Composition
1995 · W. J. Evans, J. Lexell · The Journals of Gerontology Series A · 1,308
Biodemography of human ageing
2010 · James W. Vaupel · Nature · 1,077
DNA methylation and healthy human aging
2015 · Meaghan J. Jones, Sarah J. Goodman, et al. · Aging Cell · 931
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Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age
1992 · Marisol Corral-Debrinski, Terzah Horton, et al. · Nature Genetics · 890
Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects
2015 · Jerome Mertens, Apuã C.M. Paquola, et al. · Cell stem cell · 761
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Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains
2010 · Vardhman K. Rakyan, Thomas A. Down, et al. · Genome Research · 750
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Human Ageing Genomic Resources: new and updated databases
2017 · Robi Tacutu, Daniel Thornton, et al. · Nucleic Acids Research · 736
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Mitotic Misregulation and Human Aging
2000 · Danith H. Ly, David J. Lockhart, et al. · Science · 599
Replicative and Chronological Aging in Saccharomyces cerevisiae
2012 · Valter D. Longo, Gerald S. Shadel, et al. · Cell Metabolism · 595
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Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns
2017 · Martin Enge, H. Efsun Arda, et al. · Cell · 568
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Aging and Genome Maintenance: Lessons from the Mouse?
2003 · Paul Hasty, Judith Campisi, et al. · Science · 553
A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
2015 · Weiqi Zhang, Jingyi Li, et al. · Science · 550
Nonlinear dynamics of multi-omics profiles during human aging
2024 · Xiaotao Shen, Chuchu Wang, et al. · Nature Aging · 492
Association of human aging with a functional variant of klotho
2002 · Dan E. Arking, Alice Krebsova, et al. · Proceedings of the National Academy of Sciences · 481
Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle
1999 · Patrizia Mecocci, Giorgio Fanó, et al. · Free Radical Biology and Medicine · 461
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans
2003 · Michelangela Barbieri, Massimiliano Bonafè, et al. · American Journal of Physiology-Endocrinology and Metabolism · 456
The Genetics of Aging
2001 · Caleb E. Finch, Gary Ruvkun · Annual Review of Genomics and Human Genetics · 446
Mitochondrial DNA–Deletion Mutations Accumulate Intracellularly to Detrimental Levels in Aged Human Skeletal Muscle Fibers
2006 · Entela Bua, Jody Johnson, et al. · The American Journal of Human Genetics · 440
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Human aging magnifies genetic effects on executive functioning and working memory
2008 · Irene E Nagel · Frontiers in Human Neuroscience · 413
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Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mature hydroxypyridinium residues
1988 · D R Eyre, I R Dickson, et al. · Biochemical Journal · 411
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Human ageing and the sympathoadrenal system
2000 · Douglas R. Seals, Murray D. Esler · The Journal of Physiology · 408
Melatonin, human aging, and age-related diseases
2004 · M. Karasek · Experimental Gerontology · 380
Works count: 2,738
Citation count: 60,390
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