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Keyword

hydroxyurea

Description: A cytotoxic antimetabolite drug used in hematology and other medical contexts to inhibit DNA synthesis and treat disease.
Wikidata ID: wiki/Q212272
OpenAlex ID: keywords/hydroxyurea
Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer
1999 · Peter G. Rose, Brian N. Bundy, et al. · New England Journal of Medicine · 2,661
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Sickle-cell disease
2010 · David C Rees, Thomas N Williams, et al. · The Lancet · 2,504
Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia
1995 · Samuel Charache, Michael L. Terrin, et al. · New England Journal of Medicine · 2,346
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Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint
2000 · Qinghua Liu, Saritha Guntuku, et al. · Genes & Development · 1,622
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Management of Sickle Cell Disease
2014 · Barbara P. Yawn, George R. Buchanan, et al. · JAMA · 1,599
Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix
1990 · Thomas A. Owen, Michael Aronow, et al. · Journal of Cellular Physiology · 1,568
Pain in Sickle Cell Disease
1991 · Orah S. Platt, Bruce D. Thorington, et al. · New England Journal of Medicine · 1,555
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Randomized Comparison of Fluorouracil Plus Cisplatin Versus Hydroxyurea as an Adjunct to Radiation Therapy in Stage IIB-IVA Carcinoma of the Cervix With Negative Para-Aortic Lymph Nodes: A Gynecologic Oncology Group and Southwest Oncology Group Study
1999 · Charles W. Whitney, William Sause, et al. · Journal of Clinical Oncology · 1,525
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Sickle cell disease
2018 · Gregory J. Kato, Frédéric B. Piel, et al. · Nature Reviews Disease Primers · 1,493
Regulation of Herpesvirus Macromolecular Synthesis I. Cascade Regulation of the Synthesis of Three Groups of Viral Proteins
1974 · Robert W. Honess, Bernard Roizman · Journal of Virology · 1,414
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Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11
2011 · Katharina Schlacher, Nicole Christ, et al. · Cell · 1,255
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Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress
2001 · Irene M. Ward, Junjie Chen · Journal of Biological Chemistry · 1,150
Sickle cell disease
2017 · Russell E Ware, Mariane de Montalembert, et al. · The Lancet · 979
Effect of Hydroxyurea on Mortality and Morbidity in Adult Sickle Cell Anemia
2003 · Martin H. Steinberg, Franca Barton, et al. · JAMA · 932
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Hydroxyurea Compared with Anagrelide in High-Risk Essential Thrombocythemia
2005 · Claire N. Harrison, Peter J. Campbell, et al. · New England Journal of Medicine · 927
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Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease
2016 · Kenneth I. Ataga, Abdullah Kutlar, et al. · New England Journal of Medicine · 911
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Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage
1997 · Ralph Scully, Junjie Chen, et al. · Cell · 900
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Ruxolitinib versus Standard Therapy for the Treatment of Polycythemia Vera
2015 · Alessandro M. Vannucchi, Jean Jacques Kiladjian, et al. · New England Journal of Medicine · 891
Choreography of the DNA Damage Response
2004 · Michael Lisby, Jacqueline H. Barlow, et al. · Cell · 890
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Sickle-cell disease
2004 · Marie J Stuart, Ronald L Nagel · The Lancet · 857
Cardiovascular Events and Intensity of Treatment in Polycythemia Vera
2012 · Roberto Marchioli, Guido Finazzi, et al. · New England Journal of Medicine · 850
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Philadelphia-Negative Classical Myeloproliferative Neoplasms: Critical Concepts and Management Recommendations From European LeukemiaNet
2011 · Tiziano Barbui, Giovanni Barosi, et al. · Journal of Clinical Oncology · 850
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Hydroxyurea for Patients with Essential Thrombocythemia and a High Risk of Thrombosis
1995 · Sergio Cortelazzo, Guido Finazzi, et al. · New England Journal of Medicine · 844
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Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
2010 · Eva Petermann, Manuel Luís Orta, et al. · Molecular Cell · 830
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
2000 · Shuhei Matsuoka, Galit Rotman, et al. · Proceedings of the National Academy of Sciences · 829
Works count: 20,240
Citation count: 391,500
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