Keyword

hyperforin

Description: Hyperforin is a bioactive chemical compound found in St. John's wort, studied for its pharmacological effects and biological mechanisms.

Primary topic: Natural Compound Pharmacology Studies (55%)

OpenAlex ID: keywords/hyperforin

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

2000 · Linda B. Moore, Bryan Goodwin, et al. · Proceedings of the National Academy of Sciences · 947

Indinavir concentrations and St John's wort

2000 · Stephen C Piscitelli, Aaron H Burstein, et al. · The Lancet · 874

St John's wort ( Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties

2001 · Joanne Barnes, Linda A Anderson, et al. · Journal of Pharmacy and Pharmacology · 750

Hyperforin as a possible antidepressant component of hypericum extracts

1998 · S.S. Chatterjee, S.K. Bhattacharya, et al. · Life Sciences · 443

A review of the antibacterial activity of Hypericum perforatum L.

2010 · Zeb Saddiqe, Ismat Naeem, et al. · Journal of Ethnopharmacology · 397

Inhibition of Human Cytochrome P450 Enzymes by Constituents of St. John's Wort, an Herbal Preparation Used in the Treatment of Depression

2000 · R. Scott Obach · Journal of Pharmacology and Experimental Therapeutics · 397

Vitamin K2 Regulation of Bone Homeostasis Is Mediated by the Steroid and Xenobiotic Receptor SXR

2003 · Michelle M. Tabb, Aixu Sun, et al. · Journal of Biological Chemistry · 387

Phytochemical and antioxidant characterization of Hypericum perforatum alcoholic extracts

2004 · Bruno A. Silva, Federico Ferreres, et al. · Food Chemistry · 374

Regulation of the Human CYP2B6 Gene by the Nuclear Pregnane X Receptor

2001 · Bryan Goodwin, Linda B. Moore, et al. · Molecular Pharmacology · 374

Research Progress of Polycyclic Polyprenylated Acylphloroglucinols

2018 · Xing-Wei Yang, Robert B. Grossman, et al. · Chemical Reviews · 373

Mechanism of Action of St John???s Wort in Depression

2003 · Veronika Butterweck · CNS Drugs · 369

St. John's Wort in Mild to Moderate Depression: The Relevance of Hyperforin for the Clinical Efficacy

1998 · G. Laakmann, C. Schüle, et al. · Pharmacopsychiatry · 339

2.1 Å Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin,

2003 · Ryan E. Watkins, Jodi M. Maglich, et al. · Biochemistry · 319

St John's Wort for Depression

2000 · Barak Gaster, John Holroyd · Archives of Internal Medicine · 319

Possible involvement of pregnane X receptor–enhanced CYP24 expression in drug-induced osteomalacia

2005 · Jean Marc Pascussi, Agnes Robert, et al. · Journal of Clinical Investigation · 317

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Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis

2017 · Qin Xiang Ng, Nandini Venkatanarayanan, et al. · Journal of Affective Disorders · 313

Temperature stress can alter the photosynthetic efficiency and secondary metabolite concentrations in St. John's wort

2005 · S.M.A. Zobayed, F. Afreen, et al. · Plant Physiology and Biochemistry · 294

Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations

2009 · Francesca Borrelli, Angelo A. Izzo · The AAPS Journal · 289

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St John's wort: Prozac from the plant kingdom

2001 · Giulia Di Carlo, Francesca Borrelli, et al. · Trends in Pharmacological Sciences · 279

Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis

2002 · Christoph M Schempp, Vladimir Kirkin, et al. · Oncogene · 269

Hyperforin Represents the Neurotransmitter Reuptake Inhibiting Constituent of Hypericum Extract

1998 · W. Müller, A. Singer, et al. · Pharmacopsychiatry · 269

Identification of the major constituents of Hypericum perforatum by LC/SPE/NMR and/or LC/MS

2006 · Evangelos C. Tatsis, Sjef Boeren, et al. · Phytochemistry · 260

Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria

1999 · Christoph M Schempp, Klaus Pelz, et al. · The Lancet · 258

MDR- and CYP3A4-mediated drug–herbal interactions

2006 · Dhananjay Pal, Ashim K. Mitra · Life Sciences · 254

Different effects of St John's Wort on the pharmacokinetics of simvastatin and pravastatin

2001 · Koh‐ichi Sugimoto, Masami Ohmori, et al. · Clinical Pharmacology & Therapeutics · 247

Works count: 1,656

Citation count: 46,580