Keyword

hypervariable region

Description: A hypervariable region is a segment of DNA or RNA with unusually high sequence variation, used in genetics, phylogenetics, and epidemiology.

Primary topic: Monoclonal and Polyclonal Antibodies Research (23%)

Wikidata ID: wiki/Q1047544

OpenAlex ID: keywords/hypervariable-region

Structure and function of immunoglobulins

2010 · Harry W. Schroeder, Lisa Cavacini · Journal of Allergy and Clinical Immunology · 1,921

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Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori

1999 · Richard A. Alm, Lo-See L. Ling, et al. · Nature · 1,893

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 · John F. Hancock, Anthony I. Magee, et al. · Cell · 1,799

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

1997 · L G Presta, H Chen, et al. · PubMed · 1,605

Reshaping human antibodies for therapy

1988 · Lutz Riechmann, Michael Clark, et al. · Nature · 1,562

Replacing the complementarity-determining regions in a human antibody with those from a mouse

1986 · Peter T. Jones, Paul H. Dear, et al. · Nature · 1,406

Identification of group A rotavirus gene 4 types by polymerase chain reaction

1992 · J R Gentsch, R I Glass, et al. · Journal of Clinical Microbiology · 1,400

An Analysis of the Sequences of the Variable Regions of Bence Jones Proteins and Myeloma Light Chains and Their Implications for Antibody Complementarity

1970 · Tai Te Wu, Elvin A. Kabat · The Journal of Experimental Medicine · 1,337

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IgBLAST: an immunoglobulin variable domain sequence analysis tool

2013 · Jian Ye, Ning Ma, et al. · Nucleic Acids Research · 1,192

Conformations of immunoglobulin hypervariable regions

1989 · Cyrus Chothia, Arthur M. Lesk, et al. · Nature · 1,185

Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution

1986 · A. G. Amit, R. A. Mariuzza, et al. · Science · 1,183

A detailed analysis of 16S ribosomal RNA gene segments for the diagnosis of pathogenic bacteria

2007 · Soumitesh Chakravorty, Danica Helb, et al. · Journal of Microbiological Methods · 1,152

Mitochondrial portraits of human populations using median networks.

1995 · H J Bandelt, P Forster, et al. · Genetics · 1,073

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A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 · John F. Hancock, Hugh Paterson, et al. · Cell · 1,059

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 · P. Early, H. Huang, et al. · Cell · 865

Architecture and secondary structure of an entire HIV-1 RNA genome

2009 · Joseph M. Watts, Kristen K. Dang, et al. · Nature · 836

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IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains

2002 · Marie-Paule Lefranc, Christelle Pommié, et al. · Developmental & Comparative Immunology · 820

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Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS

1986 · Bruno R. Starcich, Beatrice H. Hahn, et al. · Cell · 774

The immunogenicity of humanized and fully human antibodies

2010 · Fiona A. Harding, Marcia M. Stickler, et al. · mAbs · 741

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Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides 1 1Edited by I. A. Wilson

2000 · Achim Knappik, Liming Ge, et al. · Journal of Molecular Biology · 728

Standard conformations for the canonical structures of immunoglobulins 1 1Edited by I. A. Wilson

1997 · Bissan Al-Lazikani, Arthur M Lesk, et al. · Journal of Molecular Biology · 707

Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections.

1992 · A J Weiner, H M Geysen, et al. · Proceedings of the National Academy of Sciences · 704

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SAbDab: the structural antibody database

2013 · James Dunbar, Konrad Krawczyk, et al. · Nucleic Acids Research · 668

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.

1993 · C Pannetier, M Cochet, et al. · Proceedings of the National Academy of Sciences · 635

A humanized antibody that binds to the interleukin 2 receptor.

1989 · C Queen, W P Schneider, et al. · Proceedings of the National Academy of Sciences · 627

Works count: 6,210

Citation count: 213,200