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Keyword

IκBα

Description: IκBα is a protein that inhibits NF-κB signaling by binding NF-κB transcription factors and regulating their activity and cellular localization.
Wikidata ID: wiki/Q6103521
OpenAlex ID: keywords/ikappabalpha
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.
1991 · R. Schreck, P. Rieber, et al. · The EMBO Journal · 3,816
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NF-κB: Ten Years After
1996 · Patrick A Baeuerle, David Baltimore · Cell · 3,001
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Suppression of TNF-α-Induced Apoptosis by NF-κB
1996 · Daniel J. Van Antwerp, Seamus J. Martin, et al. · Science · 2,581
Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis
1995 · Nathalie Auphan, Joseph A. DiDonato, et al. · Science · 2,392
The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation
2002 · Alexander Hoffmann, Andre Levchenko, et al. · Science · 1,862
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
1995 · Amer A. Beg, William C. Sha, et al. · Nature · 1,825
Role of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids
1995 · Robert I. Scheinman, Patricia C. Cogswell, et al. · Science · 1,699
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.
1992 · R Schreck, B Meier, et al. · The Journal of Experimental Medicine · 1,509
Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation
2004 · Patrick Viatour, Marie-Paule Merville, et al. · Trends in Biochemical Sciences · 1,496
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Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation
1995 · Keith Brown, Susan Gerstberger, et al. · Science · 1,433
Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α
2002 · Samar I. Itani, Neil B. Ruderman, et al. · Diabetes · 1,389
Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB
2001 · Yasunori Ogura, Naohiro Inohara, et al. · Journal of Biological Chemistry · 1,362
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Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
2000 · J-P Segain, D Raingeard de la Blétière, et al. · Gut · 1,323
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Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.
1995 · Z Chen, J Hagler, et al. · Genes & Development · 1,290
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Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation
2001 · Lin-feng Chen, Wolfgang Fischle, et al. · Science · 1,227
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Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.
1996 · K Natarajan, S Singh, et al. · Proceedings of the National Academy of Sciences · 1,140
NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway
1993 · Shao-Cong Sun, Parham A. Ganchi, et al. · Science · 1,106
Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB
1993 · Thomas Henkel, Thomas Machleidt, et al. · Nature · 1,104
SUMO-1 Modification of IκBα Inhibits NF-κB Activation
1998 · Joana M.P Desterro, Manuel S Rodriguez, et al. · Molecular Cell · 1,039
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
2004 · Margit A. Huber, Ninel Azoitei, et al. · Journal of Clinical Investigation · 1,033
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Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.
1993 · A A Beg, T S Finco, et al. · Molecular and Cellular Biology · 1,027
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Phosphorylation of human I kappa B‐alpha on serines 32 and 36 controls I kappa B‐alpha proteolysis and NF‐kappa B activation in response to diverse stimuli.
1995 · E.B. Traenckner, H.L. Pahl, et al. · The EMBO Journal · 1,014
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Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
1999 · Cun-Yu Wang, James C. Cusack, et al. · Nature Medicine · 988
The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro
1999 · J. T. Winston, P. Strack, et al. · Genes & Development · 954
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Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity
1996 · Zhijian J Chen, Lana Parent, et al. · Cell · 951
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Works count: 7,444
Citation count: 351,000
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