Keyword

insulitis

Description: Insulitis is inflammation of the pancreatic islets, often involving immune-cell infiltration and associated with the development of type 1 diabetes.

Primary topic: Diabetes and associated disorders (64%)

Wikidata ID: wiki/Q922215

OpenAlex ID: keywords/insulitis

Islet-cell Antibodies in Diabetes Mellitus With Autoimmune Polyendocrine Deficiencies

1974 · GianFranco Bottazzo, Alejo Florin-Christensen, et al. · The Lancet · 1,474

Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus

1965 · Willy Gepts · Diabetes · 1,345

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

2017 · Kathrin Maedler, Pavel Sergeev, et al. · Journal of Clinical Investigation · 1,114

PDF

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 · Daniel L. Kaufman, Michael Clare-Salzler, et al. · Nature · 1,070

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

2009 · Décio L. Eizirik, Maikel L. Colli, et al. · Nature Reviews Endocrinology · 1,010

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

2002 · Kathrin Maedler, Pavel Sergeev, et al. · Journal of Clinical Investigation · 1,006

PDF

Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus

1976 · Arthur A. Like, Aldo A. Rossini · Science · 980

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 · Roland Tisch, Xiao-Dong Yang, et al. · Nature · 949

In Situ Characterization of Autoimmune Phenomena and Expression of HLA Molecules in the Pancreas in Diabetic Insulitis

1985 · Gian Franco Bottazzo, Betty M. Dean, et al. · New England Journal of Medicine · 932

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

2007 · Katharina Lahl, Christoph Loddenkemper, et al. · The Journal of Experimental Medicine · 924

Insulin-Dependent Diabetes Mellitus as an Autoimmune Disease

1994 · JEAN-FRANÇOIS BACH · Endocrine Reviews · 824

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 · Mohammed Javeed I. Ansari, Alan D. Salama, et al. · The Journal of Experimental Medicine · 814

PDF

Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

2007 · Jan A. Ehses, Aurel Perren, et al. · Diabetes · 783

PDF

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

2005 · Maki Nakayama, Norio Abiru, et al. · Nature · 758

CD25+ CD4+ T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes

2004 · Kristin V. Tarbell, Sayuri Yamazaki, et al. · The Journal of Experimental Medicine · 738

PDF

Analysis of islet inflammation in human type 1 diabetes

2008 · A Willcox, S J Richardson, et al. · Clinical & Experimental Immunology · 712

Following a diabetogenic T cell from genesis through pathogenesis

1993 · Jonathan D. Katz, Bo Wang, et al. · Cell · 696

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

2012 · Ken T. Coppieters, Francesco Dotta, et al. · The Journal of Experimental Medicine · 674

PDF

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice.

1994 · L Chatenoud, E Thervet, et al. · Proceedings of the National Academy of Sciences · 666

A Novel Subtype of Type 1 Diabetes Mellitus Characterized by a Rapid Onset and an Absence of Diabetes-Related Antibodies

2000 · Akihisa Imagawa, Toshiaki Hanafusa, et al. · New England Journal of Medicine · 652

PDF

Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes

2001 · Shayan Sharif, Guillermo A. Arreaza, et al. · Nature Medicine · 602

Genetic Control of Autoimmune Diabetes in the NOD Mouse

1995 · L S Wicker, J A Todd, et al. · Annual Review of Immunology · 589

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.

1996 · D V Serreze, H D Chapman, et al. · The Journal of Experimental Medicine · 583

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 · D J Lenschow, S C Ho, et al. · The Journal of Experimental Medicine · 583

PDF

Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients

2007 · Francesco Dotta, Stefano Censini, et al. · Proceedings of the National Academy of Sciences · 569

Works count: 4,764

Citation count: 183,200