Keyword

interim analysis

Description: Interim analysis is the statistical evaluation of accumulating data during an ongoing clinical trial, often to guide decisions about its continuation or modification.

Primary topic: Statistical Methods in Clinical Trials (57%)

Wikidata ID: wiki/Q6046661

OpenAlex ID: keywords/interim-analysis

Qualitative research in health care: Analysing qualitative data

2000 · C. Pope · BMJ · 8,122

Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial

2006 · Walter Stummer, Uwe Pichlmeier, et al. · The Lancet Oncology · 3,413

Alpha Emitter Radium-223 and Survival in Metastatic Prostate Cancer

2013 · C. Parker, S. Nilsson, et al. · New England Journal of Medicine · 3,406

Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma

2018 · Ghassan K. Abou-Alfa, Tim Meyer, et al. · New England Journal of Medicine · 2,345

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Maintenance Olaparib for Germline BRCA -Mutated Metastatic Pancreatic Cancer

2019 · Talia Golan, Pascal Hammel, et al. · New England Journal of Medicine · 2,293

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Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial

2007 · Bernard Escudier, Anna Pluzanska, et al. · The Lancet · 2,219

Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy

2017 · Norikazu Masuda, Soo-Jung Lee, et al. · New England Journal of Medicine · 1,888

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Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients

2021 · Angélica Jayk Bernal, Monica M. Gomes da Silva, et al. · New England Journal of Medicine · 1,839

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Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial

2019 · Richard S. Finn, Baek-Yeol Ryoo, et al. · Journal of Clinical Oncology · 1,786

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

2019 · Sabue Mulangu, Lori E. Dodd, et al. · New England Journal of Medicine · 1,607

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First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial

2021 · Luis Paz-Ares, Tudor-Eliade Ciuleanu, et al. · The Lancet Oncology · 1,357

Group Sequential Methods with Applications to Clinical Trials

1999 · Christopher Jennison, Bruce W. Turnbull · Chapman & Hall/CRC eBooks · 1,336

Carfilzomib, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma

2014 · A. Keith Stewart, S. Vincent Rajkumar, et al. · New England Journal of Medicine · 1,333

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Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma

2015 · Sagar Lonial, Meletios Dimopoulos, et al. · New England Journal of Medicine · 1,324

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A Randomized Trial Comparing Perioperative Chemotherapy and Surgery With Surgery Alone in Resectable Stage IIIA Non-Small-Cell Lung Cancer

1994 · J. A. Roth, F. Fossella, et al. · JNCI Journal of the National Cancer Institute · 1,111

Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis

2025 · Arun J. Sanyal, Philip N. Newsome, et al. · New England Journal of Medicine · 1,049

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Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases

1999 · Douglas Kondziolka, Atul Patel, et al. · International Journal of Radiation Oncology*Biology*Physics · 986

International Subarachnoid Aneurysm Trial (ISAT) of Neurosurgical Clipping versus Endovascular Coiling in 2,143 Patients with Ruptured Intracranial Aneurysms: A Randomized Trial

2002 · A Molyneux, R Kerr, et al. · Journal of Stroke and Cerebrovascular Diseases · 956

Alectinib versus crizotinib in patients with ALK -positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial

2017 · Toyoaki Hida, Hiroshi Nokihara, et al. · The Lancet · 911

Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct

2023 · Xiaochuan Huo, Gaoting Ma, et al. · New England Journal of Medicine · 903

Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults

2021 · Nawal Al Kaabi, Yuntao Zhang, et al. · JAMA · 776

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Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes

2020 · Shengli Xia, Kai Duan, et al. · JAMA · 759

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Ibrutinib–Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia

2019 · Tait D. Shanafelt, Xin V. Wang, et al. · New England Journal of Medicine · 750

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Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion

2022 · Tudor G. Jovin, Chuanhui Li, et al. · New England Journal of Medicine · 726

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Randomized trials stopped early for benefit: a systematic review.

2005 · Victor M Montori, P J Devereaux, et al. · PubMed · 702

Works count: 4,659

Citation count: 118,900