Keyword

IRE1

Description: IRE1 is an endoplasmic-reticulum stress sensor protein that initiates signaling in the unfolded protein response.

Primary topic: Endoplasmic Reticulum Stress and Disease (65%)

Wikidata ID: wiki/Q17917579

OpenAlex ID: keywords/ire1

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 · Hiderou Yoshida, Toshie Matsui, et al. · Cell · 4,044

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 · Heather P. Harding, Yuhong Zhang, et al. · Nature · 3,306

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 · Fumihiko Urano, XiaoZhong Wang, et al. · Science · 2,991

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 · Anne Bertolotti, Yuhong Zhang, et al. · Nature Cell Biology · 2,863

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 · Marcella Calfon, Huiqing Zeng, et al. · Nature · 2,822

Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress

2006 · Maiko Ogata, Shin-ichiro Hino, et al. · Molecular and Cellular Biology · 1,832

Decay of Endoplasmic Reticulum-Localized mRNAs During the Unfolded Protein Response

2006 · Julie Hollien, Jonathan S. Weissman · Science · 1,319

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

1993 · Jeffery S. Cox, Caroline E. Shamu, et al. · Cell · 1,231

Cell death induced by endoplasmic reticulum stress

2015 · Raffaella Iurlaro, Cristina Muñoz‐Pinedo · FEBS Journal · 1,065

Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1

2007 · Keisuke Yamamoto, Takashi Sato, et al. · Developmental Cell · 1,056

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Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

2009 · Julie Hollien, Jonathan H. Lin, et al. · The Journal of Cell Biology · 1,032

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Endoplasmic reticulum stress: molecular mechanism and therapeutic targets

2023 · Xingyi Chen, Chaoran Shi, et al. · Signal Transduction and Targeted Therapy · 1,013

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The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress

2005 · Amy S. Lee · Methods · 992

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

2003 · Neal N. Iwakoshi, Ann-Hwee Lee, et al. · Nature Immunology · 877

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

2014 · Xi Chen, Dimitrios Iliopoulos, et al. · Nature · 817

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 · Xiao‐Zhong Wang, Heather P. Harding, et al. · The EMBO Journal · 787

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Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

2013 · B. M. Gardner, D. Pincus, et al. · Cold Spring Harbor Perspectives in Biology · 723

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Linking of Autophagy to Ubiquitin-Proteasome System Is Important for the Regulation of Endoplasmic Reticulum Stress and Cell Viability

2007 · Wen-Xing Ding, Hong-Min Ni, et al. · American Journal Of Pathology · 707

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Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development

2001 · Xiaohua Shen, Ronald E. Ellis, et al. · Cell · 704

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Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

2011 · Brooke M. Gardner, Peter Walter · Science · 687

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The unfolded protein response signals through high-order assembly of Ire1

2008 · Alexei V. Korennykh, Pascal F. Egea, et al. · Nature · 652

Getting RIDD of RNA: IRE1 in cell fate regulation

2014 · M. Maurel, E. Chevet, et al. · Trends in Biochemical Sciences · 634

Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response

2000 · Yan Wang, Jingshi Shen, et al. · Journal of Biological Chemistry · 616

Initiation and execution of lipotoxic ER stress in pancreatic β-cells

2008 · Daniel A. Cunha, Paul Hekerman, et al. · Journal of Cell Science · 594

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

2012 · Benedict C. S. Cross, Peter J. Bond, et al. · Proceedings of the National Academy of Sciences · 592

Works count: 2,805

Citation count: 116,000