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IRF3
Description:
IRF3 is interferon regulatory factor 3, a transcription factor involved in innate immune responses and antiviral signaling.
Primary topic:
interferon and immune responses (49%)
Related topics:
interferon and immune responses (49%),
Immune Response and Inflammation (9%)
OpenAlex ID:
keywords/irf3
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
2004
·
Mitsutoshi Yoneyama
, Mika Kikuchi
, et al.
·
Nature Immunology
·
3,932
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
2008
·
Hiroki Ishikawa
, Glen N. Barber
·
Nature
·
3,543
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
2003
·
Masahiro Yamamoto
, Shintaro Sato
, et al.
·
Science
·
3,238
IKKε and TBK1 are essential components of the IRF3 signaling pathway
2003
·
Katherine A. Fitzgerald
, Sarah M. McWhirter
, et al.
·
Nature Immunology
·
2,680
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
2005
·
Taro Kawai
, Ken Takahashi
, et al.
·
Nature Immunology
·
2,560
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
2012
·
Jiaxi Wu
, Lijun Sun
, et al.
·
Science
·
2,545
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
2005
·
Etienne Meylan
, Joseph Curran
, et al.
·
Nature
·
2,399
PDF
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
2014
·
Seng-Ryong Woo
, Mercedes B. Fuertes
, et al.
·
Immunity
·
1,900
PDF
VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
2005
·
Liang-Guo Xu
, Yan-Yi Wang
, et al.
·
Molecular Cell
·
1,853
PDF
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
2007
·
Akinori Takaoka
, ZhiChao Wang
, et al.
·
Nature
·
1,715
Triggering the Interferon Antiviral Response Through an IKK-Related Pathway
2003
·
Sonia Sharma
, Benjamin R. tenOever
, et al.
·
Science
·
1,663
IFI16 is an innate immune sensor for intracellular DNA
2010
·
Leonie Unterholzner
, Sinead E Keating
, et al.
·
Nature Immunology
·
1,641
PDF
Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction
2000
·
Mitsuharu Sato
, Hirofumi Suemori
, et al.
·
Immunity
·
1,339
PDF
STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
2012
·
Yasuo Tanaka
, Zhijian J. Chen
·
Science Signaling
·
1,319
Regulation and Function of IKK and IKK-Related Kinases
2006
·
Hans Häcker
, Michael Karin
·
Science s STKE
·
1,274
Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4
2004
·
Eva M. Pålsson‐McDermott
, Luke A. J. O'Neill
·
Immunology
·
1,252
Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling
2002
·
Masahiro Yamamoto
, Shintaro Sato
, et al.
·
The Journal of Immunology
·
1,227
PDF
LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
2003
·
Katherine A. Fitzgerald
, Daniel C. Rowe
, et al.
·
The Journal of Experimental Medicine
·
1,193
PDF
Structural basis of STING binding with and phosphorylation by TBK1
2019
·
Conggang Zhang
, Guijun Shang
, et al.
·
Nature
·
1,076
Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity
2007
·
Yueh-Ming Loo
, Jamie Fornek
, et al.
·
Journal of Virology
·
1,071
Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
2004
·
Taro Kawai
, Shintaro Sato
, et al.
·
Nature Immunology
·
1,034
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
2006
·
R. K. Thimmulappa
·
Journal of Clinical Investigation
·
1,028
Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response
2006
·
Daniel B. Stetson
, Ruslan Medzhitov
·
Immunity
·
1,008
PDF
Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation
1998
·
Rongtuan Lin
, Christophe Heylbroeck
, et al.
·
Molecular and Cellular Biology
·
915
A Mouse Model of Zika Virus Pathogenesis
2016
·
Helen M. Lazear
, Jennifer Govero
, et al.
·
Cell Host & Microbe
·
906
PDF
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Works count:
5,480
Citation count:
239,700
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