Keyword

KAI1

Description: A human gene, also known as CD82, that encodes a cell-surface protein studied for its role in suppressing cancer metastasis.

Primary topic: Mechanisms of cancer metastasis (41%)

Wikidata ID: wiki/Q18028107

OpenAlex ID: keywords/kai1

KAI1 , a Metastasis Suppressor Gene for Prostate Cancer on Human Chromosome 11p11.2

1995 · Jin-Tang Dong, Pattie W. Lamb, et al. · Science · 758

Exchange of N-CoR Corepressor and Tip60 Coactivator Complexes Links Gene Expression by NF-κB and β-Amyloid Precursor Protein

2002 · Sung Hee Baek, Kenneth A. Ohgi, et al. · Cell · 558

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The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

2004 · Ruth C. von Rotz, Bernhard M. Kohli, et al. · Journal of Cell Science · 347

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Transcriptional regulation of a metastasis suppressor gene by Tip60 and β-catenin complexes

2005 · Jung Hwa Kim, Bogyou Kim, et al. · Nature · 291

p53 Regulates the Expression of the Tumor Suppressor Gene Maspin

2000 · Zhiqiang Zou, Chunling Gao, et al. · Journal of Biological Chemistry · 278

Down-regulation of the KAI1 metastasis suppressor gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic loss.

1996 · J T Dong, H Suzuki, et al. · PubMed · 269

Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression

2006 · Sucharita Bandyopadhyay, Rui Zhan, et al. · Nature Medicine · 237

CD44 is a metastasis suppressor gene for prostatic cancer located on human chromosome 11p13.

1997 · A C Gao, W Lou, et al. · PubMed · 197

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

2006 · Sébastien S Hébert, Lutgarde Serneels, et al. · EMBO Reports · 190

The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation

2007 · Yien Che Tsai, Arnulfo Mendoza, et al. · Nature Medicine · 186

Metastasis Suppression: The Evolving Role of Metastasis Suppressor Genes for Regulating Cancer Cell Growth at the Secondary Site

2003 · ERIC C. KAUFFMAN, VICTORIA L. ROBINSON, et al. · The Journal of Urology · 184

Tumour suppressor gene expression correlates with gastric cancer prognosis

2003 · Hye Seung Lee, Hyeon Kook Lee, et al. · The Journal of Pathology · 180

KAI1 expression is up-regulated in early pancreatic cancer and decreased in the presence of metastases.

1996 · X Guo, H Friess, et al. · PubMed · 165

Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases

2005 · S C Sridhar, C K Miranti · Oncogene · 162

The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53

1998 · Tomoyuki Mashimo, Misako Watabe, et al. · Proceedings of the National Academy of Sciences · 149

Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis

2006 · Jung Hwa Kim, Hee June Choi, et al. · Nature Cell Biology · 148

Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases

2004 · Andreas M. Stark, Kerrin Tongers, et al. · Journal of Cancer Research and Clinical Oncology · 147

Metastasis Suppressor Genes: Basic Biology and Potential Clinical Use

2003 · Patricia S. Steeg, Taoufik Ouatas, et al. · Clinical Breast Cancer · 140

Loss of KAI1 expression in the progression of colorectal cancer.

1999 · D P Lombardi, J Geradts, et al. · PubMed · 129

Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB

2004 · Jeena Joseph, Giridhar Mudduluru, et al. · Oncogene · 128

Epstein-Barr Virus-Positive Gastric Carcinoma Has a Distinct Protein Expression Profile in Comparison with Epstein-Barr Virus-Negative Carcinoma

2004 · Hye Seung Lee, Mee Soo Chang, et al. · Clinical Cancer Research · 125

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Overexpression of KAI1 suppresses in vitro invasiveness and in vivo metastasis in breast cancer cells.

2001 · X Yang, L L Wei, et al. · PubMed · 121

Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAI1 gene

1998 · Akinori Takaoka, Yuji Hinoda, et al. · Oncogene · 113

The role of metastasis suppressor genes in metastatic dormancy

2008 · CHRISTINE E. HORAK, JONG HEUN LEE, et al. · Apmis · 110

Loss of KAI1 messenger RNA expression in both high-grade and invasive human bladder cancers.

1997 · Y Yu, J L Yang, et al. · PubMed · 110

Works count: 698

Citation count: 12,530